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1-Stearoyl-2-arachidonoyl-sn-glycerol (CAS 65914-84-3)

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Alternate Names:
1-O-Hexadecyl-2-o-arachidonyl-sn-glycerol
Application:
1-Stearoyl-2-arachidonoyl-sn-glycerol is a diacylglycerol derivative and activator of PKC
CAS Number:
65914-84-3
Purity:
≥95%
Molecular Weight:
645.0
Molecular Formula:
C41H72O5
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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1-Stearoyl-2-arachidonoyl-sn-glycerol is a diacylglycerol derivative, and an endogenous activator of PKC (protein kinase C). 1-Stearoyl-2-arachidonoyl-sn-glycerol is produced via receptor-mediated inositol phospholipid hydrolysis. 1-Stearoyl-2-arachidonoyl-sn-glycerol is an activator of PKCbeta, PKCepsilon and PKCalpha. This vital component forms the phospholipid bilayer in cell membranes and plays a role in regulating cellular processes. Additionally, it participates in various physiological functions, including cell signaling, inflammation, and apoptosis.


1-Stearoyl-2-arachidonoyl-sn-glycerol (CAS 65914-84-3) References

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  2. Diacylglycerols containing Omega 3 and Omega 6 fatty acids bind to RasGRP and modulate MAP kinase activation.  |  Madani, S., et al. 2004. J Biol Chem. 279: 1176-83. PMID: 14583629
  3. AtDGK2, a novel diacylglycerol kinase from Arabidopsis thaliana, phosphorylates 1-stearoyl-2-arachidonoyl-sn-glycerol and 1,2-dioleoyl-sn-glycerol and exhibits cold-inducible gene expression.  |  Gómez-Merino, FC., et al. 2004. J Biol Chem. 279: 8230-41. PMID: 14665624
  4. Activation of the Ca(2+)-activated nonselective cation channel by diacylglycerol analogues in rat cardiomyocytes.  |  Guinamard, R., et al. 2004. J Cardiovasc Electrophysiol. 15: 342-8. PMID: 15030426
  5. Diacylglycerol-containing docosahexaenoic acid in acyl chain modulates airway smooth muscle tone.  |  Hichami, A., et al. 2005. Am J Respir Cell Mol Biol. 33: 378-86. PMID: 15961724
  6. Bovine brain diacylglycerol lipase: substrate specificity and activation by cyclic AMP-dependent protein kinase.  |  Rosenberger, TA., et al. 2007. Lipids. 42: 187-95. PMID: 17393225
  7. Compartmentalization of endocannabinoids into lipid rafts in a dorsal root ganglion cell line.  |  Rimmerman, N., et al. 2008. Br J Pharmacol. 153: 380-9. PMID: 17965731
  8. High-performance liquid chromatographic assay with ultraviolet spectrometric detection for the evaluation of inhibitors of phosphatidylinositol-specific phospholipase C.  |  Schmolke, M., et al. 2008. Anal Biochem. 375: 291-8. PMID: 18191462
  9. 1-Peptidyl-2-arachidonoyl-3-stearoyl-sn-glyceride: an immunologically active lipopeptide from goat serum (Capra hircus) is an endogenous damage-associated molecular pattern.  |  Thacker, JD., et al. 2009. J Nat Prod. 72: 1993-9. PMID: 19835390
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  12. Further studies on the specificity of diacylglycerol for protein kinase C activation.  |  Go, M., et al. 1987. Biochem Biophys Res Commun. 144: 598-605. PMID: 3579933
  13. Diacylglycerol elevations in control platelets are unaccompanied by pleckstrin phosphorylation. Implications for the role of diacylglycerol in platelet activation.  |  Fukami, MH. and Holmsen, H. 1995. Eur J Biochem. 228: 579-86. PMID: 7737151
  14. Calphostin C-sensitive enhancements of force by lysophosphatidylinositol and diacylglycerols in mesenteric arteries from the rat.  |  Jensen, PE. 1996. Br J Pharmacol. 119: 15-22. PMID: 8872351
  15. Substitution of 15(S)hydroxyeicosatetraenoic acid in phosphatidylinositol alters the growth of liver epithelial cells.  |  Vernhet, L., et al. 1997. Life Sci. 61: 1667-78. PMID: 9363982

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

1-Stearoyl-2-arachidonoyl-sn-glycerol, 10 mg

sc-202864
10 mg
$175.00