1-Phenylimidazole (CAS 7164-98-9)
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1-Phenylimidazole (1-PI) is an aromatic heterocyclic compound consisting of a benzene ring fused to an imidazole ring. This versatile organic compound finds widespread utility across various fields, including organic synthesis, chemical biology, and biochemistry. In scientific research, 1-Phenylimidazole has been extensively employed. It serves as a key component in the synthesis of organic compounds, including heterocyclic compounds, and natural products. Moreover, 1-Phenylimidazole proves valuable in investigating protein-protein interactions and studying enzyme kinetics. 1-Phenylimidazole exhibits competitive inhibition by binding to the active site of enzymes, effectively preventing their catalytic activity. As a reversible inhibitor, it binds reversibly to the enzyme′s active site, enabling modulation of its function. This reversible binding restricts the enzyme from carrying out its intended reaction.
1-Phenylimidazole (CAS 7164-98-9) References
- Synthesis and identification of the quaternary ammonium-linked glucuronide of 1-phenylimidazole in human liver microsomes and investigation of the human UDP-glucuronosyltransferases involved. | Vashishtha, SC., et al. 2000. Drug Metab Dispos. 28: 1009-13. PMID: 10950841
- Quaternary ammonium-linked glucuronidation of 1-substituted imidazoles by liver microsomes: interspecies differences and structure-metabolism relationships. | Vashishtha, SC., et al. 2002. Drug Metab Dispos. 30: 1070-6. PMID: 12228182
- Interplanar torsion in the S1
- Induction of EROD activity by 1-phenylimidazole and beta-naphthoflavone in rainbow trout cultured hepatocytes: a comparative study. | Jos, A., et al. 2007. Toxicol In Vitro. 21: 1307-10. PMID: 17521864
- Influence of metabolic factors on the mutagenic effectiveness of cyclophosphamide in Drosophila melanogaster. | Zijlstra, JA. and Vogel, EW. 1989. Mutat Res. 210: 79-92. PMID: 2491914
- Covalent binding of 1,2-dihaloalkanes to DNA and stability of the major DNA adduct, S-[2-(N7-guanyl)ethyl]glutathione. | Inskeep, PB., et al. 1986. Cancer Res. 46: 2839-44. PMID: 2870801
- Chemotaxis by Pseudomonas putida (ATCC 17453) towards camphor involves cytochrome P450cam (CYP101A1). | Balaraman, P. and Plettner, E. 2019. Biochim Biophys Acta Gen Subj. 1863: 304-312. PMID: 30391161
- Influence of inhibition of the metabolic activation on the mutagenicity of some nitrosamines, triazenes, hydrazines and seniciphylline in Drosophila melanogaster. | Zijlstra, JA. and Vogel, EW. 1988. Mutat Res. 202: 251-67. PMID: 3141806
- Clinically used antifungal azoles as ligands for gold(III) complexes: the influence of the Au(III) ion on the antimicrobial activity of the complex. | Stevanović, NL., et al. 2022. Dalton Trans. 51: 5322-5334. PMID: 35293926
- Metabolism of vinyltoluene in the rat: effect of induction and inhibition of the cytochrome. | Heinonen, TH. 1984. Biochem Pharmacol. 33: 1585-93. PMID: 6428412
- Selectivity of 1-phenylimidazole as a ligand for cytochrome P-450 and as an inhibitor of microsomal oxidation. | Wilkinson, CF., et al. 1983. Biochem Pharmacol. 32: 997-1003. PMID: 6838663
- Interferon-gamma-inducible murine macrophage nitric oxide synthase: studies on the mechanism of inhibition by imidazole agents. | Wolff, DJ. and Gribin, BJ. 1994. Arch Biochem Biophys. 311: 293-9. PMID: 7515612
- The inhibition of the constitutive bovine endothelial nitric oxide synthase by imidazole and indazole agents. | Wolff, DJ., et al. 1994. Arch Biochem Biophys. 314: 360-6. PMID: 7526799
- Calmodulin-dependent nitric-oxide synthase. Mechanism of inhibition by imidazole and phenylimidazoles. | Wolff, DJ., et al. 1993. J Biol Chem. 268: 9425-9. PMID: 7683651
- Furan-mediated uncoupling of hepatic oxidative phosphorylation in Fischer-344 rats: an early event in cell death. | Mugford, CA., et al. 1997. Toxicol Appl Pharmacol. 144: 1-11. PMID: 9169064
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
1-Phenylimidazole, 1 g | sc-253947 | 1 g | $56.00 |