Molecular structure of 1-Phenylbiguanide, CAS Number: 102-02-3
1-Phenylbiguanide (CAS 102-02-3)
Application:
1-Phenylbiguanide is a SR (5-hydroxytryptamine receptor) agonist
CAS Number:
102-02-3
Molecular Weight:
177.21
Molecular Formula:
C8H11N5
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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Description
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SDS & Certificate of Analysis
1-Phenylbiguanide is a SR (5-hydroxytryptamine receptor) agonist and increases extracellular dopamine release in rat nucleus accumbens in vivo. It serves as building block for synthesis of heterocyclic compounds.
1-Phenylbiguanide (CAS 102-02-3) References
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- Activation of 5-HT3 receptor by 1-phenylbiguanide increases dopamine release in the rat nucleus accumbens. | Chen, JP., et al. 1991. Brain Res. 543: 354-7. PMID: 1711914
- Improved performance of SPECT-CT In-111 capromab pendetide by correlation with diffusion-weighted magnetic resonance imaging for identifying metastatic pelvic lymphadenopathy in prostate cancer. | Hardie, AD., et al. 2013. World J Urol. 31: 1327-32. PMID: 23595605
- Influence of central noradrenergic system lesion on the serotoninergic 5-HT3 receptor mediated analgesia in rats. | Roczniak, W., et al. 2013. Adv Clin Exp Med. 22: 629-38. PMID: 24285447
- Interaction of a biguanide compound with membrane model interface systems: probing the properties of antimalaria and antidiabetic compounds. | Samart, N., et al. 2014. Langmuir. 30: 8697-706. PMID: 24956022
- Measures of cardiovascular function suggest autonomic nervous system dysregulation after surgical induction of joint injury in the male Lewis rat. | Yeater, TD., et al. 2022. Osteoarthritis Cartilage. 30: 586-595. PMID: 35017058
- Inhibitory effects of 2-guanidinebenzimidazole and 1-phenylbiguanide on gastric acid secretion in rats. | Pinelli, A., et al. 1984. Arzneimittelforschung. 34: 890-4. PMID: 6093826
- Inhibitory 5-hydroxytryptamine receptors involved in pressor effects obtained by stimulation of sympathetic outflow from spinal cord in pithed rats. | Morán, A., et al. 1994. Br J Pharmacol. 113: 1358-62. PMID: 7889292
- Behavioral effects of the 5-hydroxytryptamine3 receptor agonists 1-phenylbiguanide and m-chlorophenylbiguanide in rats. | Higgins, GA., et al. 1993. J Pharmacol Exp Ther. 264: 1440-9. PMID: 8450478
- Stereochemistry of serotonin receptor ligands from crystallographic data. Crystal structures of NAN-190.HBr, 1-phenylbiguanide, MDL 72222 and mianserin.HCl and selectivity criteria towards 5-HT1, 5-HT2, and 5-HT3 receptor subtypes. | Dalpiaz, A., et al. 1996. Acta Crystallogr B. 52 (Pt 3): 509-18. PMID: 8767764
- Structure-activity relationships for the binding of arylpiperazines and arylbiguanides at 5-HT3 serotonin receptors. | Dukat, M., et al. 1996. J Med Chem. 39: 4017-26. PMID: 8831767
- Several receptor subtypes contribute to 5-hydroxytryptamine-induced secretion by rat ileum in-vitro. | Hardcastle, J. and Hardcastle, PT. 1997. J Pharm Pharmacol. 49: 1114-20. PMID: 9401948
- 5-Hydroxytryptamine-induced secretion by rat jejunum in-vitro involves several 5-hydroxytryptamine receptor subtypes. | Hardcastle, J. and Hardcastle, PT. 1998. J Pharm Pharmacol. 50: 539-47. PMID: 9643448
Activator of:
M13 Major Coat Protein, and SR.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
1-Phenylbiguanide, 25 g | sc-222728 | 25 g | $427.00 |