1-Phenacylpyridinium bromide (CAS 16883-69-5)
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1-Phenacylpyridinium bromide is a chemical compound that functions as a quaternary ammonium compound. It acts as a potent inhibitor of acetylcholinesterase, an enzyme responsible for the breakdown of the neurotransmitter acetylcholine. By inhibiting this enzyme, 1-Phenacylpyridinium bromide disrupts the normal degradation of acetylcholine, leading to an accumulation of the neurotransmitter at the synaptic cleft. This accumulation results in prolonged stimulation of cholinergic receptors, ultimately leading to overstimulation and subsequent paralysis of the neuromuscular junction. At the molecular level, 1-Phenacylpyridinium bromide binds to the active site of acetylcholinesterase, preventing the enzyme from carrying out its normal function. This mechanism of action may be useful for studying the role of acetylcholinesterase in neurotransmission and for investigating potential strategies for conditions involving cholinergic dysfunction.
1-Phenacylpyridinium bromide (CAS 16883-69-5) References
- [3 + 2]-Annulation of pyridinium ylides with 1-chloro-2-nitrostyrenes unveils a tubulin polymerization inhibitor. | Aksenov, AV., et al. 2021. Org Biomol Chem. 19: 7234-7245. PMID: 34387294
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
1-Phenacylpyridinium bromide, 25 g | sc-222724 | 25 g | $102.00 |