1-Palmitoyl-2-linoleoyl PE (CAS 26662-95-3)

1-Palmitoyl-2-linoleoyl PE (phosphatidylethanolamine) is a phospholipid molecule where the glycerol backbone is esterified with palmitic acid at the first position and linoleic acid at the second position, linked to an ethanolamine headgroup. This specific composition of saturated and unsaturated fatty acids, combined with the unique properties of the ethanolamine headgroup, makes it an important lipid in the study of membrane biology and lipid-protein interactions. The presence of linoleic acid, a polyunsaturated fatty acid, introduces a degree of fluidity and disorder within the lipid bilayer, which is critical for understanding membrane dynamics such as vesicle formation, fusion, and permeability. Additionally, the ethanolamine headgroup contributes to the molecule′s overall headgroup charge and polarity, influencing interactions with proteins and other membrane components. In research, 1-Palmitoyl-2-linoleoyl PE is extensively used to simulate and study the structural and functional properties of biological membranes. It provides insights into how variations in fatty acid composition can affect the biophysical properties of membranes and influence cellular signaling pathways, particularly those related to membrane curvature and trafficking. This phospholipid is also applied in studies aiming to explain the role of specific lipid environments in modulating protein function and localization within the cell, thereby offering a deeper understanding of membrane-associated processes in cellular physiology.