1-Palmitoyl-2-[3-(diphenylhexatriene)propanoyl]-sn-phosphatidylcholine (CAS 98014-38-1)

1-Palmitoyl-2-[3-(diphenylhexatriene)propanoyl]-sn-phosphatidylcholine (DPH-PC), identified by CAS number 98014-38-1, is a specialized fluorescent phospholipid analog extensively utilized in biophysical research, particularly in the study of lipid membranes. This molecule incorporates a diphenylhexatriene (DPH) moiety, a robust fluorescent probe, into the sn-2 position of a phosphatidylcholine, which is a major component of cellular membranes. The DPH group is particularly notable for its sensitivity to the polarity of its environment, making DPH-PC an invaluable tool for exploring the dynamic behavior of lipid bilayers and the organization of lipids within these structures. Researchers employ this compound to monitor phase transitions in membranes, to study membrane fluidity, and to investigate how various proteins, peptides, and other molecules interact with lipid bilayers. The fluorescence properties of DPH, which include a high quantum yield and a relatively long fluorescence lifetime, allow for detailed and precise measurements. These characteristics are critical when using techniques such as fluorescence spectroscopy and microscopy, which can provide insights into the microscopic properties of membranes at both molecular and supra-molecular levels. The application of DPH-PC in these areas helps explain fundamental aspects of membrane biochemistry and biophysics, contributing significantly to our understanding of membrane-associated processes in cells.