Molecular structure of 1-O-Palmityl-2-arachidonoyl-sn-glycero-3-phosphocholine, CAS Number: 86288-11-1
1-O-Palmityl-2-arachidonoyl-sn-glycero-3-phosphocholine (CAS 86288-11-1)
Alternate Names:
Arachidonoyl PAF C-16
Application:
1-O-Palmityl-2-arachidonoyl-sn-glycero-3-phosphocholine is a phospholipid precursor of PAF
CAS Number:
86288-11-1
Molecular Weight:
768.2
Molecular Formula:
C44H82NO7P
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
A phospholipid biosynthetic precursor of platelet-activating factor (PAF). Platelet-activating factor (PAF) is a pro-inflammatory lipid mediator that activates many cell types including leukocytes, platelets and vascular endothelial cells in response to cutaneous inflammation. PAF is produced by two distinct enzymatic pathways. One remodeling route involves structural modification of a membrane phospholipid (1-alkyl-2-acyl-sn-glycero-3-phosphocholine). 1-O-Hexadecyl-2-O-arachidonoyl-sn-glycero-3-phosphorylcholine has been used to examine substrate dependence and the effect on deacylation of alkylarachidonoyl-GPC by platelet phospholipase A2.
1-O-Palmityl-2-arachidonoyl-sn-glycero-3-phosphocholine (CAS 86288-11-1) References
- Platelet-activating factor. | Prescott, SM., et al. 1990. J Biol Chem. 265: 17381-4. PMID: 2170377
- Hydrolysis of 1-alkyl-2-arachidonoyl-sn-glycero-3-phosphocholine, a common precursor of platelet-activating factor and eicosanoids, by human platelet phospholipase A2. | Kramer, RM., et al. 1988. Biochim Biophys Acta. 959: 269-79. PMID: 3355850
- 1-O-alkyl-2-arachidonoyl-sn-glycero-3-phosphocholine. A common source of platelet-activating factor and arachidonate in human polymorphonuclear leukocytes. | Chilton, FH., et al. 1984. J Biol Chem. 259: 12014-9. PMID: 6434535
- Metabolism of platelet-activating factor in human platelets. Transacylase-mediated synthesis of 1-O-alkyl-2-arachidonoyl-sn-glycero-3-phosphocholine. | Kramer, RM., et al. 1984. J Biol Chem. 259: 13316-20. PMID: 6436245
- Enzymatic studies of lyso platelet-activating factor acylation in human neutrophils and changes upon stimulation. | Venable, ME., et al. 1993. J Biol Chem. 268: 7965-75. PMID: 8463317
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
1-O-Palmityl-2-arachidonoyl-sn-glycero-3-phosphocholine, 5 mg | sc-201013 | 5 mg | $189.00 | |||
1-O-Palmityl-2-arachidonoyl-sn-glycero-3-phosphocholine, 25 mg | sc-201013A | 25 mg | $726.00 |