Molecular structure of 1-O-Hexyl-2,3,5-trimethylhydroquinone, CAS Number: 148081-72-5
1-O-Hexyl-2,3,5-trimethylhydroquinone (CAS 148081-72-5)
Alternate Names:
HTHQ; 4-Hexyloxy-2,3,6-trimethylphenol; 4-(Hexyloxy)-2,3,6-trimethyl-phenol
Application:
1-O-Hexyl-2,3,5-trimethylhydroquinone is an antioxidant and antimutagenic agent used in cancer research
CAS Number:
148081-72-5
Molecular Weight:
236.35
Molecular Formula:
C15H24O2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
1-O-Hexyl-2,3,5-trimethylhydroquinone (1-HHTQ) is a novel phenolic antioxidant that shows strong antimutagenic activity against eight carcinogenic heterocyclic amines (HCA) produced during cooking processes. The antimutagenic activity inhibits metabolic activation of HCA. 1-O-Hexyl-2,3,5-trimethylhydroquinone is known to have antioxidant, anti-inflammatory, and anticancer properties by scavenging free radicals, inhibiting the production of pro-inflammatory mediators, and inducing apoptosis in cancer cells. Furthermore, it has been studied as a potential neuroprotective agent in cell culture models of neurodegenerative diseases.
1-O-Hexyl-2,3,5-trimethylhydroquinone (CAS 148081-72-5) References
- Chemoprevention of 2-amino-1-methyl-6-phenylimidazo- [4,5-b]pyridine-induced colon carcinogenesis by 1-O-hexyl-2,3,5-trimethylhydroquinone after initiation with 1,2-dimethylhydrazine in F344 rats. | Futakuchi, M., et al. 2002. Carcinogenesis. 23: 283-7. PMID: 11872633
- 1-O-hexyl-2,3,5-trimethylhydroquinone inhibits IkappaB phosphorylation and degradation-linked inducible nitric oxide synthase expression: beyond antioxidant function. | Liu, W., et al. 2002. J Pharm Pharmacol. 54: 383-9. PMID: 11902804
- Effects of 1-O-hexyl-2,3,5-trimethylhydroquinone on carbon tetrachloride-induced hepatic cirrhosis in rats. | An, J., et al. 2010. Hepatol Res. 40: 613-21. PMID: 20412328
- Inhibitory Effect of 1-O-Hexyl-2,3,5-Trimethylhydroquinone on Dimethylnitrosamine-induced Liver Fibrosis in Male SD Rats. | Jung, YR., et al. 2010. Toxicol Res. 26: 193-201. PMID: 24278524
- 1-O-Hexyl-2,3,5-Trimethylhydroquinone Ameliorates l-DOPA-Induced Cytotoxicity in PC12 Cells. | Park, HJ., et al. 2019. Molecules. 24: PMID: 30823626
- Neuroprotective effects of 1-O-hexyl-2,3,5-trimethylhydroquinone on ischaemia/reperfusion-induced neuronal injury by activating the Nrf2/HO-1 pathway. | Tang, C., et al. 2020. J Cell Mol Med. 24: 10468-10477. PMID: 32677362
- 1-O-Hexyl-2,3,5-Trimethylhydroquinone Ameliorates the Development of Preeclampsia through Suppression of Oxidative Stress and Endothelial Cell Apoptosis. | Jiang, L., et al. 2021. Oxid Med Cell Longev. 2021: 8839394. PMID: 33542786
- Strong anti-mutagenic activity of the novel lipophilic antioxidant 1-O-hexyl-2,3,5-trimethylhydroquinone against heterocyclic amine-induced mutagenesis in the Ames assay and its effect on metabolic activation of 2-amino-6-methyldipyrido[1,2-a:3',2'-d] imidazole (Glu-p-1). | Hirose, M., et al. 1995. Carcinogenesis. 16: 2227-32. PMID: 7554080
- Strong inhibition of 2-amino-6-methyldipyrido[1,2-a:3',2'-d] imidazole-induced mutagenesis and hepatocarcinogenesis by 1-O-hexyl-2,3,5-trimethylhydroquinone. | Hirose, M., et al. 1993. Jpn J Cancer Res. 84: 481-4. PMID: 8320163
- Inhibitory effects of 1-O-hexyl-2,3,5-trimethylhydroquinone (HTHQ), green tea catechins and other antioxidants on 2-amino-6-methyldipyrido[1,2-a:3',2'-d]imidazole (Glu-P-1)-induced rat hepatocarcinogenesis and dose-dependent inhibition by HTHQ of lesion induction by Glu-P-1 or 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline (MeIQx). | Hirose, M., et al. 1995. Carcinogenesis. 16: 3049-55. PMID: 8603484
- Dose dependence of 1-O-hexyl-2,3,5-trimethylhydroquinone promotion of forestomach carcinogenesis in rats pretreated with N-ethylnitrosourethane. | Mizoguchi, Y., et al. 1998. Jpn J Cancer Res. 89: 475-80. PMID: 9685849
- HTHQ (1-O-hexyl-2,3,5-trimethylhydroquinone), an anti-lipid-peroxidative compound: its chemical and biochemical characterizations. | Hino, T., et al. 1998. Biochim Biophys Acta. 1425: 47-60. PMID: 9813237
- Inhibition of DMBA-initiated rat mammary tumour development by 1-O-hexyl-2,3,5-trimethylhydroquinone, phenylethyl isothiocyanate, and novel synthetic ascorbic acid derivatives. | Futakuchi, M., et al. 1998. Eur J Cancer Prev. 7: 153-9. PMID: 9818778
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
1-O-Hexyl-2,3,5-trimethylhydroquinone, 100 mg | sc-206192 | 100 mg | $306.00 |