1-O-Hexadecyl-2-O-dihomo-γ-linolenoyl-sn-glycero-3-phosphorylcholine (CAS 155575-01-2)

1-O-Hexadecyl-2-O-dihomo-γ-linolenoyl-sn-glycero-3-phosphorylcholine, a synthetic plasmalogen analog, is utilized in biochemical and cellular research to study the role of ether lipids in cell membrane structure and signaling. This compound mimics naturally occurring plasmalogens, which are integral components of biological membranes, especially in the brain and heart. Its unique ether linkage and polyunsaturated fatty acid tail provide insights into plasmalogen-specific functions. Researchers employ this phospholipid to investigate its involvement in membrane fluidity, fusion, and signaling pathways. It has been instrumental in studying the protective antioxidant properties of plasmalogens and their role in reducing lipid peroxidation in cellular membranes. Moreover, its structural similarity to endogenous plasmalogens allows scientists to explore their regulatory effects on phospholipase activities and cellular lipid metabolism. Through biochemical assays and cellular models, 1-O-hexadecyl-2-O-dihomo-γ-linolenoyl-sn-glycero-3-phosphorylcholine helps explain the role of ether-linked phospholipids in modulating membrane-associated protein functions. Recent research also leverages it to examine plasmalogen deficiencies in metabolic and neurodegenerative diseases, shedding light on its critical role in cellular homeostasis and oxidative stress response. This compound thus continues to be pivotal in uncovering the complex functions of plasmalogens in cellular biochemistry.