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1-O-Dodecyl-rac-glycerol (CAS 1561-07-5)

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Alternate Names:
3-Dodecyloxypropane-1,2-diol
Application:
1-O-Dodecyl-rac-glycerol is an antibacterial agent known to stimulate autolysin activity
CAS Number:
1561-07-5
Purity:
≥97%
Molecular Weight:
260.4
Molecular Formula:
C15H32O3
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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1-O-Dodecyl-rac-glycerol is a synthetic glycerol ether that is utilized in a variety of research applications, particularly in the study of lipid bilayers and surfactant systems. Due to its amphiphilic nature, with a hydrophobic dodecyl chain and a hydrophilic glycerol moiety, this compound is useful for probing the physicochemical properties of membrane models. Researchers employ it to understand the dynamics of lipid monolayers and bilayers, which are fundamental components of biological membranes. In the field of materials science, 1-O-Dodecyl-rac-glycerol is used to stabilize nanoemulsions and liposomes, which have potential applications in chemical delivery systems and the creation of advanced materials. Additionally, it serves as a mimetic for naturally occurring lipids, allowing for the study of lipid-protein interactions that are for cell signaling and metabolism.


1-O-Dodecyl-rac-glycerol (CAS 1561-07-5) References

  1. Dietary ether lipid incorporation into tissue plasmalogens of humans and rodents.  |  Das, AK., et al. 1992. Lipids. 27: 401-5. PMID: 1630273
  2. New insights into the prevention of staphylococcal infections and toxic shock syndrome.  |  Lin, YC. and Peterson, ML. 2010. Expert Rev Clin Pharmacol. 3: 753-767. PMID: 21625323
  3. Organophosphate agents induce plasma hypertriglyceridemia in mouse via single or dual inhibition of the endocannabinoid hydrolyzing enzyme(s).  |  Suzuki, H., et al. 2014. Toxicol Lett. 225: 153-7. PMID: 24361246
  4. Activation of mouse peritoneal macrophages by lysophospholipids and ether derivatives of neutral lipids and phospholipids.  |  Yamamoto, N. and Ngwenya, BZ. 1987. Cancer Res. 47: 2008-13. PMID: 2950993
  5. Characterizing the Membrane-Disruptive Behavior of Dodecylglycerol Using Supported Lipid Bilayers.  |  Yoon, BK., et al. 2019. Langmuir. 35: 3568-3575. PMID: 30720282
  6. Functional lipidomics of vascular endothelial cells in response to laminar shear stress.  |  Hirata, T., et al. 2021. FASEB J. 35: e21301. PMID: 33421194
  7. An Overview of the Supramolecular Systems for Gene and Drug Delivery in Tissue Regeneration.  |  Ranamalla, SR., et al. 2022. Pharmaceutics. 14: PMID: 36015356
  8. Metabolism of orally administered rac-1-O-[1'-14C]dodecylglycerol and nutritional effects of dietary rac-1-O-dodecylglycerol in mice.  |  Weber, N. 1985. J Lipid Res. 26: 1412-20. PMID: 4086944
  9. Dodecylglycerol. A new type of antibacterial agent which stimulates autolysin activity in Streptococcus faecium ATCC 9790.  |  Ved, HS., et al. 1984. J Biol Chem. 259: 8115-21. PMID: 6145712
  10. The involvement of the proteinase of Streptococcus faecium ATCC 9790 in the stimulation of its autolysin activity by dodecylglycerol.  |  Ved, HS., et al. 1984. J Biol Chem. 259: 8122-4. PMID: 6145713
  11. Growth-dependent accumulation of monoalkylglycerol in Madin-Darby canine kidney cells. Evidence for a role in the regulation of protein kinase C.  |  Warne, TR., et al. 1995. J Biol Chem. 270: 11147-54. PMID: 7744745
  12. Inhibition of phorbol ester-stimulated arachidonic acid release by alkylglycerols.  |  Robinson, M., et al. 1995. Biochim Biophys Acta. 1254: 361-7. PMID: 7857977
  13. Participation of serum proteins in the inflammation-primed activation of macrophages.  |  Yamamoto, N., et al. 1994. Inflammation. 18: 311-22. PMID: 8088927
  14. Dynamic remodeling of giant unilamellar vesicles induced by monoglyceride nano-micelles: Insights into supramolecular organization  |  BK Yoon, MC Kim, JA Jackman, NJ Cho. 2021. Applied Materials Today. 24: 101099.

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

1-O-Dodecyl-rac-glycerol, 1 g

sc-201997
1 g
$231.00

1-O-Dodecyl-rac-glycerol, 10 g

sc-201997A
10 g
$1485.00