1-O-Acetyl-2,3,5-tri-O-benzoyl-β-D-ribofuranose (CAS 6974-32-9)

1-O-Acetyl-2,3,5-tri-O-benzoyl-β-D-ribofuranose is a chemical compound widely utilized in carbohydrate chemistry research due to its importance as a key intermediate in the synthesis of nucleosides and nucleotides. Its mechanism of action primarily revolves around its role as a protecting group for the ribose moiety during glycosylation reactions. The acetyl and benzoyl groups selectively shield the hydroxyl functionalities at the 1st, 2nd, 3rd, and 5th positions of the ribose ring, enabling precise control over glycosylation reactions. This compound has been extensively employed in the synthesis of modified nucleosides and nucleotides for investigating structure-activity relationships, enzymatic mechanisms, and nucleic acid interactions. Researchers utilize it as a building block in the assembly of nucleic acid analogs and mimics for studying RNA and DNA biology, including RNA interference (RNAi) and gene editing. Additionally, it finds applications in the synthesis of nucleotide analogs as potential antiviral and anticancer agents. Its versatility in carbohydrate chemistry makes it an indispensable tool for the synthesis of complex nucleoside and nucleotide derivatives, advancing our understanding of nucleic acid structure and function and contributing to the development of novel nucleic acid-based technologies