1-NBD-decanoyl-2-decanoyl-sn-glycerol
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1-NBD-decanoyl-2-decanoyl-sn-glycerol is produced by the hydrolysis of membrane phospholipids and acts as lipid second messengers, activating PKC and regulating cell growth and apoptosis. It also serves as a substrate for DAG kinases for the production of phosphatidic acid, another important lipid messenger. 1-NBD-decanoyl-2-decanoyl-sn-glycerol has the fluorophore nitrobenzoxadiazole (NBD) attached to the omega-end of the terminal decanoyl chain of the model DAG, 1,2-didecanoyl-sn-glycerol. Fluorescently-tagged lipids have been used to study their interactions with proteins, their utilization by cells and liposomes, and for the development of assays for lipid metabolism. 1-NBD-decanoyl-2-decanoyl-sn-glycerol are generated through the breakdown of phospholipids in cellular membranes. They play a role as lipid second messengers, triggering the activation of PKC and regulating cell growth and apoptosis. Additionally, they function as substrates for DAG kinases, which produce phosphatidic acid—an important lipid messenger.
1-NBD-decanoyl-2-decanoyl-sn-glycerol References
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- Nuclear localization of 5-lipoxygenase as a determinant of leukotriene B4 synthetic capacity. | Luo, M., et al. 2003. Proc Natl Acad Sci U S A. 100: 12165-70. PMID: 14530386
- CERT mediates intermembrane transfer of various molecular species of ceramides. | Kumagai, K., et al. 2005. J Biol Chem. 280: 6488-95. PMID: 15596449
- Expression of Soluble Forms of Yeast Diacylglycerol Acyltransferase 2 That Integrate a Broad Range of Saturated Fatty Acids in Triacylglycerols. | Haïli, N., et al. 2016. PLoS One. 11: e0165431. PMID: 27780240
- A Pair of Arabidopsis Diacylglycerol Kinases Essential for Gametogenesis and Endoplasmic Reticulum Phospholipid Metabolism in Leaves and Flowers. | Angkawijaya, AE., et al. 2020. Plant Cell. 32: 2602-2620. PMID: 32471859
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
1-NBD-decanoyl-2-decanoyl-sn-glycerol, 500 µg | sc-220475 | 500 µg | $167.00 | |||
1-NBD-decanoyl-2-decanoyl-sn-glycerol, 1 mg | sc-220475A | 1 mg | $317.00 |