1-NBD-decanoyl-2-decanoyl-sn-glycerol MF: C29H46N4O8
MW: 578.70
A lipid second messenger and DAG kinase substrate.

1-NBD-decanoyl-2-decanoyl-sn-glycerol

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Alternate Names: 1-NBD-1,2-bis(O-decanoyl-sn-glycerol)
Application: 1-NBD-decanoyl-2-decanoyl-sn-glycerol is a lipid second messenger and DAG kinase substrate
Molecular Weight: 578.70
Molecular Formula: C29H46N4O8
Supplemental Information: This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).
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1-NBD-decanoyl-2-decanoyl-sn-glycerol is produced by the hydrolysis of membrane phospholipids and acts as lipid second messengers, activating PKC and regulating cell growth and apoptosis. It also serves as a substrate for DAG kinases for the production of phosphatidic acid, another important lipid messenger. 1-NBD-decanoyl-2-decanoyl-sn-glycerol has the fluorophore nitrobenzoxadiazole (NBD) attached to the ω-end of the terminal decanoyl chain of the model DAG, 1,2-didecanoyl-sn-glycerol. Fluorescently-tagged lipids have been used to study their interactions with proteins, their utilization by cells and liposomes, and for the development of assays for lipid metabolism.


References

1. Kumagai, K., et al. 2005. J. Biol. Chem. 280: 6488-6495. PMID: 15596449
2. Luo, M., et al. 2003. Proc. Natl. Acad. Sci. U.S.A. 100: 12165-12170. PMID: 14530386
3. Tani, M., et al. 1999. J. Biochem. 125: 746-749. PMID: 10101288

Formulation :
A solution in ethanol
Physical State :
Liquid
Storage :
Store at -80° C
Boiling Point :
78° C
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
Transport :
UN 1170, Class 3, Packing group II
PubChem CID :
53394414
SMILES :
CCCCCCCCCC(=O)OC(CO)COC(=O)CCCCCCCCCNC1=CC=C(C2=NON=C12)[N+](=O)[O-]

Download SDS (MSDS)

Certificate of Analysis

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