Date published: 2025-12-5

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1-Naphthyl acetate (CAS 830-81-9)

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Alternate Names:
α-Naphthyl acetate
Application:
1-Naphthyl acetate is a useful staining tool for identification of macrophages
CAS Number:
830-81-9
Molecular Weight:
186.21
Molecular Formula:
C12H10O2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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1-Naphthyl acetate is a chemical compound that functions as a substrate for the enzyme esterase in various experimental. When introduced into a reaction, it undergoes hydrolysis by esterase, resulting in the formation of 1-naphthol and acetic acid. 1-Naphthyl acetate reaction is utilized to measure esterase activity in biological samples, as the release of 1-naphthol can be quantitatively measured using spectrophotometric methods. The mode of action of 1-naphthyl acetate involves its interaction with esterase enzymes, leading to the cleavage of the acetate group and the subsequent release of 1-naphthol. This process allows for the assessment of esterase activity in a variety of experimental applications, providing insights into biological processes and enzymatic function.


1-Naphthyl acetate (CAS 830-81-9) References

  1. Characterization and affinity purification of juvenile hormone esterase from Bombyx mori.  |  Shiotsuki, T., et al. 2000. Biosci Biotechnol Biochem. 64: 1681-7. PMID: 10993156
  2. 1-Naphthyl Acetate-Dependent Medium Acidification by Zea mays L. Coleoptile Segments.  |  Salguero, J., et al. 1991. Plant Physiol. 95: 1174-80. PMID: 16668108
  3. Plasma phenylacetate and 1-naphthyl acetate hydrolyzing activities of wild birds as possible non-invasive biomarkers of exposure to organophosphorus and carbamate insecticides.  |  Sogorb, MA., et al. 2007. Toxicol Lett. 168: 278-85. PMID: 17174487
  4. Thermodynamics of the hydrolysis reactions of 1-naphthyl acetate, 4-nitrophenyl acetate, and 4-nitrophenyl α-L-arabinofuranoside.  |  Decker, SR., et al. 2010. J Phys Chem B. 114: 16060-7. PMID: 20361764
  5. Photochemical primary process of photo-Fries rearrangement reaction of 1-naphthyl acetate as studied by MFE probe.  |  Gohdo, M., et al. 2011. Phys Chem Chem Phys. 13: 755-61. PMID: 21046042
  6. Poly[[aqua-(1-naphthyl-acetato)cadmium(II)]-μ(3)-pyridin-3-olato].  |  Ma, CY., et al. 2007. Acta Crystallogr Sect E Struct Rep Online. 64: m31. PMID: 21200605
  7. (5,5'-Dimethyl-2,2'-bipyridine-κN,N')(1-naphthyl-acetato-κO)(1-naphthyl-acetato-κO,O')zinc hemihydrate.  |  Ji, LL., et al. 2011. Acta Crystallogr Sect E Struct Rep Online. 67: m606. PMID: 21754324
  8. Bis-(2-methyl-1H-imidazole-κN)bis[2-(naphthalen-2-yl)acetato-κO]copper(II).  |  Yin, FJ., et al. 2011. Acta Crystallogr Sect E Struct Rep Online. 67: m1772. PMID: 22199565
  9. Catalytic characteristics of plant-esterase from wheat flour.  |  Hou, CJ., et al. 2012. World J Microbiol Biotechnol. 28: 541-8. PMID: 22806849
  10. Bacterial Expression and Kinetic Analysis of Carboxylesterase 001D from Helicoverpa armigera.  |  Li, Y., et al. 2016. Int J Mol Sci. 17: 493. PMID: 27049381
  11. In vitro and in vivo studies of cholinesterases and carboxylesterases in Planorbarius corneus exposed to a phosphorodithioate insecticide: Finding the most sensitive combination of enzymes, substrates, tissues and recovery capacity.  |  Otero, S. and Kristoff, G. 2016. Aquat Toxicol. 180: 186-195. PMID: 27723570
  12. 1-Naphthyl acetate: A chromogenic substrate for the detection of erythrocyte acetylcholinesterase activity.  |  Chowdhary, S., et al. 2018. Biochimie. 154: 194-209. PMID: 30201403
  13. Spheroid-3D and Monolayer-2D Intestinal Electrochemical Biosensor for Toxicity/Viability Testing: Applications in Drug Screening, Food Safety, and Environmental Pollutant Analysis.  |  Flampouri, E., et al. 2019. ACS Sens. 4: 660-669. PMID: 30698007
  14. A novel fluorescence based assay for the detection of organophosphorus pesticide exposed cholinesterase activity using 1-naphthyl acetate.  |  Chowdhary, S., et al. 2019. Biochimie. 160: 100-112. PMID: 30822441
  15. An enzyme inhibition-based lab-in-a-syringe device for point-of-need determination of pesticides.  |  Yang, L., et al. 2020. Analyst. 145: 3958-3966. PMID: 32319482

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

1-Naphthyl acetate, 5 g

sc-213375
5 g
$63.00

1-Naphthyl acetate, 25 g

sc-213375A
25 g
$242.00