Molecular structure of 1-Naphthol β-D-glucuronide, CAS Number: 17238-47-0
1-Naphthol β-D-glucuronide (CAS 17238-47-0)
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Alternate Names:
1-Naphthalenyl β-D-Glucopyranosiduronic Acid; α-Naphthol Glucuronide
Application:
1-Naphthol β-D-glucuronide is a metabolite of 1-Naphthol
CAS Number:
17238-47-0
Purity:
≥94%
Molecular Weight:
320.29
Molecular Formula:
C16H16O7
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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1-Naphthol β-D-glucuronide, also known as 1-Naphthyl glucuronide, is a metabolite that arises from the breakdown of naphthalene, a polycyclic aromatic hydrocarbon found in environmental pollutants like cigarette smoke and diesel exhaust. The liver enzymatically produces this compound through UDP-glucuronosyltransferase (UGT), which is later eliminated through urine. Extensive research has been conducted on this substance, exploring its potential as a biomarker for naphthalene and other polycyclic aromatic hydrocarbon exposures. In occupational and environmental studies, 1-Naphthol β-D-glucuronide has been widely employed as a biomarker of naphthalene exposure. Moreover, it has played a role in investigating the metabolism and toxicokinetics of naphthalene in both humans and animals.
1-Naphthol β-D-glucuronide (CAS 17238-47-0) References
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- High glucuronidation activity of environmental estrogens in the carp (Cyprinus carpino) intestine. | Yokota, H., et al. 2002. Life Sci. 71: 887-98. PMID: 12084386
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- Human udp-glucuronosyltransferases: isoform selectivity and kinetics of 4-methylumbelliferone and 1-naphthol glucuronidation, effects of organic solvents, and inhibition by diclofenac and probenecid. | Uchaipichat, V., et al. 2004. Drug Metab Dispos. 32: 413-23. PMID: 15039294
- Assessment of catechol induction and glucuronidation in rat liver microsomes. | Elovaara, E., et al. 2004. Drug Metab Dispos. 32: 1426-33. PMID: 15371300
- Polycyclic aromatic hydrocarbon (PAH) metabolizing enzyme activities in human lung, and their inducibility by exposure to naphthalene, phenanthrene, pyrene, chrysene, and benzo(a)pyrene as shown in the rat lung and liver. | Elovaara, E., et al. 2007. Arch Toxicol. 81: 169-82. PMID: 16906435
- Critical roles of residues 36 and 40 in the phenol and tertiary amine aglycone substrate selectivities of UDP-glucuronosyltransferases 1A3 and 1A4. | Kubota, T., et al. 2007. Mol Pharmacol. 72: 1054-62. PMID: 17636046
- Influence of N-terminal domain histidine and proline residues on the substrate selectivities of human UDP-glucuronosyltransferase 1A1, 1A6, 1A9, 2B7, and 2B10. | Kerdpin, O., et al. 2009. Drug Metab Dispos. 37: 1948-55. PMID: 19487247
- Absorption and presystemic glucuronidation of 1-naphthol in the vasculary fluorocarbon emulsion perfused rat small intestine: the influence of the luminal flow rate and intraluminal binding. | de Vries, MH., et al. 1989. Naunyn Schmiedebergs Arch Pharmacol. 340: 583-7. PMID: 2615849
- Absorption and presystemic glucuronidation of 1-naphthol in the vascularly fluorocarbon emulsion perfused rat small intestine. The influence of 1-naphthol concentration, perfusate flow and noradrenaline. | de Vries, MH., et al. 1989. Naunyn Schmiedebergs Arch Pharmacol. 340: 239-45. PMID: 2812036
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
1-Naphthol β-D-glucuronide, 1 mg | sc-208665 | 1 mg | $710.00 |