Molecular structure of 1-Methylthymine, CAS Number: 4160-72-9
1-Methylthymine (CAS 4160-72-9)
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Alternate Names:
1-MethylH; 1MT; 2,4-Dihydroxy-1,5-dimethylpyrimidine
Application:
1-Methylthymine is a methylated analog of thymidine which can acts as a protecting group
CAS Number:
4160-72-9
Molecular Weight:
140.14
Molecular Formula:
C6H8N2O2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
1-Methylthymine is a model of thymidine, which is found naturally in DNA. The compound is found on DNA as a result of the affinity of the methyl group located on the N1 atom towards the deoxyribose moiety. Studies indicate that 1-Methylthymine is useful as a protective group in plantination reactions of trans-Pt(NH3)2(1-MeT)Cl with DNA olionucleotides. In addition, 1-Methylthymine is essential in detecting hydrogen bonded complexes and metal complexes.
1-Methylthymine (CAS 4160-72-9) References
- Vibrational spectra of 1-methylthymine: matrix isolation, solid state and theoretical studies. | Morzyk-Ociepa, B., et al. 2004. Spectrochim Acta A Mol Biomol Spectrosc. 60: 2113-23. PMID: 15248994
- Electronic and vibrational spectroscopy of 1-methylthymine and its water clusters: the dark state survives hydration. | Busker, M., et al. 2008. Chemphyschem. 9: 1570-7. PMID: 18618888
- Rare tautomers of 1-methyluracil and 1-methylthymine: tuning relative stabilities through coordination to PtII complexes. | van der Wijst, T., et al. 2009. Chemistry. 15: 209-18. PMID: 19058265
- Intersystem crossing and characterization of dark states in the pyrimidine nucleobases uracil, thymine, and 1-methylthymine. | Etinski, M., et al. 2009. J Phys Chem A. 113: 11809-16. PMID: 19670894
- On the nature of the long-lived 'dark' state of isolated 1-methylthymine. | Kunitski, M., et al. 2011. Chemphyschem. 12: 2024-30. PMID: 21472961
- The (5-4) and (6-4) adducts of 1-methylthymine and their Dewar valence isomers. | Shetlar, MD. and Chung, J. 2011. Photochem Photobiol. 87: 802-17. PMID: 21477079
- The (α-4) photoconjugates of 5-methylcytosine, 1,5-dimethylcytosine, 1-methylthymine and thymidine. | Shetlar, MD. and Chung, J. 2012. Photochem Photobiol. 88: 336-43. PMID: 22211580
- Self-pairing of 1-methylthymine mediated by two and three Ag(I) ions: a gas phase study using infrared dissociation spectroscopy and density functional theory. | Nosenko, Y., et al. 2016. Phys Chem Chem Phys. 18: 8491-501. PMID: 26940234
- Hydrogen-Bonding Interactions of 8-Substituted Purine Derivatives. | Osifová, Z., et al. 2023. ACS Omega. 8: 25538-25548. PMID: 37483191
- Rebuttal to the article Pathological crystal structures. | Chen, H., et al. 2024. Acta Crystallogr C Struct Chem.. PMID: 38885045
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
1-Methylthymine, 1 g | sc-206183 | 1 g | $734.00 |