Date published: 2025-10-15

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1-Methylpsilocin (CAS 1465-16-3)

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Application:
1-Methylpsilocin is a potent and selective SR-2C agonist
CAS Number:
1465-16-3
Molecular Weight:
218.29
Molecular Formula:
C13H18N2O
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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1-Methylpsilocin is a compound of interest within the field of neuroscience, where it is studied for its biological properties and structural similarity to naturally occurring tryptamines. It is particularly useful in research aimed at understanding the binding affinity and activity at serotonin receptors, which are implicated in mood and perception. Its effects on these receptors are valuable for mapping out neural pathways and could contribute to the design of new molecules that can modulate these critical systems in the brain. Additionally, 1-Methylpsilocin is employed in comparative studies alongside other substances to elucidate the role of molecular modifications on pharmacokinetics.


1-Methylpsilocin (CAS 1465-16-3) References

  1. Differential contributions of serotonin receptors to the behavioral effects of indoleamine hallucinogens in mice.  |  Halberstadt, AL., et al. 2011. J Psychopharmacol. 25: 1548-61. PMID: 21148021
  2. Head-twitch response in rodents induced by the hallucinogen 2,5-dimethoxy-4-iodoamphetamine: a comprehensive history, a re-evaluation of mechanisms, and its utility as a model.  |  Canal, CE. and Morgan, D. 2012. Drug Test Anal. 4: 556-76. PMID: 22517680
  3. Support for 5-HT2C receptor functional selectivity in vivo utilizing structurally diverse, selective 5-HT2C receptor ligands and the 2,5-dimethoxy-4-iodoamphetamine elicited head-twitch response model.  |  Canal, CE., et al. 2013. Neuropharmacology. 70: 112-21. PMID: 23353901
  4. Effect of Hallucinogens on Unconditioned Behavior.  |  Halberstadt, AL. and Geyer, MA. 2018. Curr Top Behav Neurosci. 36: 159-199. PMID: 28224459
  5. Effect of 5-HT2C receptor agonist and antagonist on chronic unpredictable stress (CUS) - Mediated anxiety and depression in adolescent Wistar albino rat: Implicating serotonin and mitochondrial ETC-I function in serotonergic neurotransmission.  |  Wankhar, W., et al. 2020. Behav Brain Res. 393: 112780. PMID: 32579979
  6. Structure-Activity Relationship Analysis of Psychedelics in a Rat Model of Asthma Reveals the Anti-Inflammatory Pharmacophore.  |  Flanagan, TW., et al. 2021. ACS Pharmacol Transl Sci. 4: 488-502. PMID: 33860179

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

1-Methylpsilocin, 10 mg

sc-203764
10 mg
$204.00

1-Methylpsilocin, 50 mg

sc-203764A
50 mg
$714.00