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1-Methylhistamine dihydrochloride (CAS 6481-48-7)

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Alternate Names:
1-Methyl-4-(β-aminoethyl)imidazole dihydrochloride
CAS Number:
6481-48-7
Molecular Weight:
198.09
Molecular Formula:
C6H11N32HCl
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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1-Methylhistamine dihydrochloride is a chemical utilized predominantly in biochemical research as a selective agonist for studying the histamine H3 receptor subtype. As a structural analog of histamine, it is employed to probe the physiological and pharmacological roles of H3 receptors, which are implicated in the modulation of neurotransmitter release. This compound aids in the exploration of the mechanisms underlying neurotransmission and the regulation of circadian rhythms, due to the H3 receptor′s involvement in sleep-wake cycles. Research involving 1-Methylhistamine dihydrochloride also contributes to the understanding of feeding behavior and energy homeostasis. In addition, this agent serves as useful in signal transduction studies, helping to elucidate the pathways that mediate the various biological effects of histamine.


1-Methylhistamine dihydrochloride (CAS 6481-48-7) References

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  2. The effects of castration on histamine levels and 24-hour rhythm in the male rat hypothalamus.  |  Orr, EL. and Quay, WB. 1975. Endocrinology. 97: 481-4. PMID: 1157765
  3. Ameliorative effects of histamine on 7-chlorokynurenic acid-induced spatial memory deficits in rats.  |  Nishiga, M. and Kamei, C. 2003. Psychopharmacology (Berl). 166: 360-5. PMID: 12601505
  4. An immunoassay for histamine based on monoclonal antibodies.  |  Hammar, E., et al. 1990. J Immunol Methods. 128: 51-8. PMID: 1691234
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  6. Receptor-independent, vacuolar ATPase-mediated cellular uptake of histamine receptor-1 ligands: possible origin of pharmacological distortions and side effects.  |  Morissette, G., et al. 2008. Toxicol Appl Pharmacol. 229: 320-31. PMID: 18328520
  7. Histamine and tele-methylhistamine quantification in cerebrospinal fluid from narcoleptic subjects by liquid chromatography tandem mass spectrometry with precolumn derivatization.  |  Croyal, M., et al. 2011. Anal Biochem. 409: 28-36. PMID: 20932951
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Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

1-Methylhistamine dihydrochloride, 25 mg

sc-258820
25 mg
$140.00

1-Methylhistamine dihydrochloride, 250 mg

sc-258820A
250 mg
$94.00

1-Methylhistamine dihydrochloride, 500 mg

sc-258820B
500 mg
$148.00

1-Methylhistamine dihydrochloride, 1 g

sc-258820C
1 g
$199.00