Molecular structure of 1-Methylguanine, CAS Number: 938-85-2
1-Methylguanine (CAS 938-85-2)
See product citations (2)
Alternate Names:
2-Amino-6-hydroxy-1-methylpurine
CAS Number:
938-85-2
Purity:
≥95%
Molecular Weight:
165.15
Molecular Formula:
C6H7N5O
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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1-Methylguanine is a naturally occurring nucleobase found in DNA and RNA. It belongs to the class of 6-oxopurines, which are purines with a C=O group at position 6. Purine is an aromatic compound consisting of a fused pyrimidine ring and an imidazole ring. 1-Methylguanine is slightly soluble in water and weakly acidic based on its pKa. It occurs as a DNA lesion resulting from exposure to mutagens like alkylating agents. This compound has the ability to form hydrogen bonds with cytosine in DNA, potentially leading to mispairing during DNA replication.
1-Methylguanine (CAS 938-85-2) References
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- Recognition and processing of a new repertoire of DNA substrates by human 3-methyladenine DNA glycosylase (AAG). | Lee, CY., et al. 2009. Biochemistry. 48: 1850-61. PMID: 19219989
- A non-heme iron-mediated chemical demethylation in DNA and RNA. | Yi, C., et al. 2009. Acc Chem Res. 42: 519-29. PMID: 19852088
- Structural and mutational analysis of Escherichia coli AlkB provides insight into substrate specificity and DNA damage searching. | Holland, PJ. and Hollis, T. 2010. PLoS One. 5: e8680. PMID: 20084272
- Repair of DNA Alkylation Damage by the Escherichia coli Adaptive Response Protein AlkB as Studied by ESI-TOF Mass Spectrometry. | Li, D., et al. 2010. J Nucleic Acids. 2010: 369434. PMID: 21048928
- Implications for damage recognition during Dpo4-mediated mutagenic bypass of m1G and m3C lesions. | Rechkoblit, O., et al. 2011. Structure. 19: 821-32. PMID: 21645853
- Removal of N-alkyl modifications from N(2)-alkylguanine and N(4)-alkylcytosine in DNA by the adaptive response protein AlkB. | Li, D., et al. 2013. Chem Res Toxicol. 26: 1182-7. PMID: 23773213
- Functional identification of the hypoxanthine/guanine transporters YjcD and YgfQ and the adenine transporters PurP and YicO of Escherichia coli K-12. | Papakostas, K., et al. 2013. J Biol Chem. 288: 36827-40. PMID: 24214977
- Adaptive Response Enzyme AlkB Preferentially Repairs 1-Methylguanine and 3-Methylthymine Adducts in Double-Stranded DNA. | Chen, F., et al. 2016. Chem Res Toxicol. 29: 687-93. PMID: 26919079
- Alternated Branching Ratios by Anomaly in Collision-Induced Dissociation of Proton-Bound Hoogsteen Base Pairs of 1-Methylcytosine with 1-Methylguanine and 9-Methylguanine. | Park, JJ. and Han, SY. 2019. J Am Soc Mass Spectrom. 30: 846-854. PMID: 30911905
- Structural Determinants for Substrate Selectivity in Guanine Deaminase Enzymes of the Amidohydrolase Superfamily. | Shek, R., et al. 2019. Biochemistry. 58: 3280-3292. PMID: 31283204
- Development and validation of a rapid LC-MS/MS method for determination of methylated nucleosides and nucleobases in urine. | Raćkowska, E., et al. 2019. J Chromatogr B Analyt Technol Biomed Life Sci. 1128: 121775. PMID: 31493699
- Effect of Genistein Supplementation on the Progression of Neoplasms and the Level of the Modified Nucleosides in Rats With Mammary Cancer. | Banys, K., et al. 2021. In Vivo. 35: 2059-2072. PMID: 34182481
- [Metabonomic study of biochemical changes in serum of PCPA-induced insomnia rats after treatment with Suanzaoren Decoction]. | Liu, JX., et al. 2022. Zhongguo Zhong Yao Za Zhi. 47: 1632-1641. PMID: 35347962
- Effect of Polyphenols and Zinc Co-Supplementation on the Development of Neoplasms in Rats with Breast Cancer. | Jastrzębska, M., et al. 2023. Foods. 12: PMID: 36673448
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
1-Methylguanine, 250 mg | sc-224751 | 250 mg | $180.00 |