Molecular structure of 1-Methyladenosine, CAS Number: 15763-06-1
1-Methyladenosine (CAS 15763-06-1)
See product citations (4)
Alternate Names:
1-Methyladenosine is also known as 1-methyl Ado.
Application:
1-Methyladenosine is a modified nucleoside used as a biomarker in the early detection of several forms of cancer.
CAS Number:
15763-06-1
Molecular Weight:
281.27
Molecular Formula:
C11H15N5O4
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
1-Methyladenosine is a modified nucleoside generated by the processing of tRNA by methyltransferases. The urinary excretion of 1-Methyladenosine is elevated in several forms of cancer, supporting its use as a biomarker in early detection. 1-Methyladenosine can also be monitored in serum. Urinary levels of 1-Methyladenosine also increase during active rheumatoid arthritis.
1-Methyladenosine (CAS 15763-06-1) References
- Methylation and processing of transfer ribonucleic acid in mammalian and bacterial cells. | Munns, TW. and Sims, HF. 1975. J Biol Chem. 250: 2143-9. PMID: 1090617
- Glycyrrhizin inhibits R5 HIV replication in peripheral blood monocytes treated with 1-methyladenosine. | Takei, M., et al. 2005. Pathobiology. 72: 117-23. PMID: 15860928
- Monitoring of urinary excretion of modified nucleosides in cancer patients using a set of six monoclonal antibodies. | Reynaud, C., et al. 1992. Cancer Lett. 61: 255-62. PMID: 1739950
- Molecularly imprinted polymers for solid-phase extraction of 1-methyladenosine from human urine. | Scorrano, S., et al. 2010. Anal Chim Acta. 659: 167-71. PMID: 20103120
- New archaeal methyltransferases forming 1-methyladenosine or 1-methyladenosine and 1-methylguanosine at position 9 of tRNA. | Kempenaers, M., et al. 2010. Nucleic Acids Res. 38: 6533-43. PMID: 20525789
- Trmt61B is a methyltransferase responsible for 1-methyladenosine at position 58 of human mitochondrial tRNAs. | Chujo, T. and Suzuki, T. 2012. RNA. 18: 2269-76. PMID: 23097428
- Urinary nucleosides as biomarkers of breast, colon, lung, and gastric cancer in Taiwanese. | Hsu, WY., et al. 2013. PLoS One. 8: e81701. PMID: 24367489
- High-throughput sequencing for 1-methyladenosine (m(1)A) mapping in RNA. | Tserovski, L., et al. 2016. Methods. 107: 110-21. PMID: 26922842
- ALKBH3 partner ASCC3 mediates P-body formation and selective clearance of MMS-induced 1-methyladenosine and 3-methylcytosine from mRNA. | Wollen, KL., et al. 2021. J Transl Med. 19: 287. PMID: 34217309
- m1A-pred: Prediction of Modified 1-methyladenosine Sites in RNA Sequences through Artificial Intelligence. | Suleman, MT. and Khan, YD. 2022. Comb Chem High Throughput Screen. 25: 2473-2484. PMID: 35718969
- Initiator tRNA lacking 1-methyladenosine is targeted by the rapid tRNA decay pathway in evolutionarily distant yeast species. | Tasak, M. and Phizicky, EM. 2022. PLoS Genet. 18: e1010215. PMID: 35901126
- 1-Methyladenosine. Dimroth rearrangement and reversible reduction. | Macon, JB. and Wolfenden, R. 1968. Biochemistry. 7: 3453-8. PMID: 5681457
- Modified nucleosides of Bacillus subtilis transfer ribonucleic acids. | Vold, B. 1976. J Bacteriol. 127: 258-67. PMID: 819419
- Relationship between urinary excretion of modified nucleosides and rheumatoid arthritis process. | Tebib, JG., et al. 1997. Br J Rheumatol. 36: 990-5. PMID: 9376997
- The essential Gcd10p-Gcd14p nuclear complex is required for 1-methyladenosine modification and maturation of initiator methionyl-tRNA. | Anderson, J., et al. 1998. Genes Dev. 12: 3650-62. PMID: 9851972
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
1-Methyladenosine, 50 mg | sc-216121C | 50 mg | $104.00 | |||
1-Methyladenosine, 100 mg | sc-216121D | 100 mg | $156.00 | |||
1-Methyladenosine, 250 mg | sc-216121 | 250 mg | $312.00 | |||
1-Methyladenosine, 500 mg | sc-216121A | 500 mg | $500.00 | |||
1-Methyladenosine, 1 g | sc-216121B | 1 g | $780.00 |