Molecular structure of 1-Methyl-DL-tryptophan, CAS Number: 26988-72-7
1-Methyl-DL-tryptophan (CAS 26988-72-7)
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CAS Number:
26988-72-7
Purity:
97%
Molecular Weight:
218.25
Molecular Formula:
C12H14N2O2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
1-Methyl-DL-tryptophan is a chemical compound that functions as an inhibitor of the enzyme indoleamine 2,3-dioxygenase (IDO). Its mechanism of action involves interfering with the conversion of tryptophan to kynurenine, which is a key step in the kynurenine pathway. By inhibiting IDO, 1-Methyl-DL-tryptophan can modulate the immune response and affect the balance of T cell subsets. In experimental applications, 1-Methyl-DL-tryptophan is utilized to explore the molecular pathways involved in immune modulation.
1-Methyl-DL-tryptophan (CAS 26988-72-7) References
- Indoleamine 2,3-dioxygenase activity and L-tryptophan transport in human breast cancer cells. | Travers, MT., et al. 2004. Biochim Biophys Acta. 1661: 106-12. PMID: 14967480
- 1-Methyl-DL-tryptophan, beta-(3-benzofuranyl)-DL-alanine (the oxygen analog of tryptophan), and beta-[3-benzo(b)thienyl]-DL-alanine (the sulfur analog of tryptophan) are competitive inhibitors for indoleamine 2,3-dioxygenase. | Cady, SG. and Sono, M. 1991. Arch Biochem Biophys. 291: 326-33. PMID: 1952947
- Novel 1-alkyl-tryptophan derivatives downregulate IDO1 and IDO2 mRNA expression induced by interferon-gamma in dendritic cells. | Sun, T., et al. 2010. Mol Cell Biochem. 342: 29-34. PMID: 20424892
- Pro-inflammatory cytokines downregulate Hsp27 and cause apoptosis of human retinal capillary endothelial cells. | Nahomi, RB., et al. 2014. Biochim Biophys Acta. 1842: 164-74. PMID: 24252613
- Inhibition of indoleamine 2,3-dioxygenase activity accelerates skin wound healing. | Ito, H., et al. 2015. Biomaterials. 53: 221-8. PMID: 25890721
- Effect of the association of 1-methyl-DL-tryptophan with paclitaxel on the expression of indoleamine 2,3-dioxygenase in cultured cancer cells from patients with breast cancer. | Salvadori, ML., et al. 2015. Med Oncol. 32: 248. PMID: 26442514
- The Combined Use of Melatonin and an Indoleamine 2,3-Dioxygenase-1 Inhibitor Enhances Vaccine-Induced Protective Cellular Immunity to HPV16-Associated Tumors. | Moreno, ACR., et al. 2018. Front Immunol. 9: 1914. PMID: 30186285
- Lithium attenuates d-amphetamine-induced hyperlocomotor activity in mice via inhibition of interaction between cyclooxygenase-2 and indoleamine-2,3-dioxygenase. | Phan, DH., et al. 2020. Clin Exp Pharmacol Physiol. 47: 790-797. PMID: 31883280
- Developing immune-regulatory materials using immobilized monosaccharides with immune-instructive properties. | Alobaid, MA., et al. 2020. Mater Today Bio. 8: 100080. PMID: 33205040
- 1-MT grafted carboxymethyl chitosan and its nanoparticles: Preparation, characterization and evaluation. | Li, J., et al. 2021. Eur J Pharm Sci. 162: 105829. PMID: 33819624
- Brain Kynurenine Pathway and Functional Outcome of Rats Resuscitated From Cardiac Arrest. | Lucchetti, J., et al. 2021. J Am Heart Assoc. 10: e021071. PMID: 34816736
- Involvement of kynurenine pathway between inflammation and glutamate in the underlying etiopathology of CUMS-induced depression mouse model. | Wu, X., et al. 2022. BMC Neurosci. 23: 62. PMID: 36357867
- Polypeptide nanoformulation-induced immunogenic cell death and remission of immunosuppression for enhanced chemoimmunotherapy. | Feng, X., et al. 2021. Sci Bull (Beijing). 66: 362-373. PMID: 36654416
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
1-Methyl-DL-tryptophan, 250 mg | sc-224746 | 250 mg | $102.00 |