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1-Methyl-2-pyrrolidinone (CAS 872-50-4)

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Alternate Names:
N-Methylpyrrolid-2-one; NMP
Application:
1-Methyl-2-pyrrolidinone is a pyrrolidinone compound
CAS Number:
872-50-4
Purity:
≥99%
Molecular Weight:
99.13
Molecular Formula:
C5H9NO
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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1-Methyl-2-pyrrolidinone, often abbreviated as NMP, is a polar aprotic solvent with the chemical formula C5H9NO. This compound is a colorless liquid that possesses a high boiling point and excellent solvency properties, making it extremely useful in a variety of industrial and research applications. Due to its ability to dissolve a wide range of polymers, including polyvinyl chloride (PVC) and polyamide, NMP is widely used in the production of plastics and fibers. Its effectiveness as a solvent stems from its polar nature and the presence of both a carbonyl group and a nitrogen atom, which enable it to form strong hydrogen bonds and dissolve various organic compounds that are otherwise difficult to solubilize. In research, NMP is particularly valuable in the field of chemical synthesis and material processing, where it facilitates the manipulation and transformation of high-molecular-weight polymers. It is also employed in the electronics industry for the stripping and cleaning of photolithographic resists. Additionally, NMP′s unique properties make it a useful medium for the study of organic reactions, especially those involving sensitive reagents and intermediates, as it can provide a stable environment that minimizes unwanted side reactions. In the realm of materials science, NMP is used to prepare graphene dispersions and other nanomaterials, where its solvating capabilities ensure the uniformity and stability of suspensions.


1-Methyl-2-pyrrolidinone (CAS 872-50-4) References

  1. Solubility improvement of drugs using N-methyl pyrrolidone.  |  Sanghvi, R., et al. 2008. AAPS PharmSciTech. 9: 366-76. PMID: 18431671
  2. Facile synthesis of MOF-177 by a sonochemical method using 1-methyl-2-pyrrolidinone as a solvent.  |  Jung, DW., et al. 2010. Dalton Trans. 39: 2883-7. PMID: 20200716
  3. Aneuploidy induction in Saccharomyces cerevisiae by two solvent compounds, 1-methyl-2-pyrrolidinone and 2-pyrrolidinone.  |  Mayer, VW., et al. 1988. Environ Mol Mutagen. 11: 31-40. PMID: 3276507
  4. Gel filtration of protected peptides on Enzacryl K2 in dimethylformamide and N-methyl-2-pyrrolidone.  |  Galpin, IJ., et al. 1976. J Chromatogr. 123: 237-42. PMID: 950355
  5. Alkyl nitrate nitration of active methylene compounds. Nitration of 1-methyl4-piperidone, 1-methyl-2-pyrrolidinone and 1,3-dimethyl-2-pyrrolidinone  |  Feuer, H., Blecker, L. R., Jans Jr, R. W., & Frost, J. W. 1979. Journal of Heterocyclic Chemistry. 16(3): 481-485.
  6. Reduction of aldehydes and ketones using sodium formate in 1-methyl-2-pyrrolidinone  |  Babler, J. H., & Sarussi, S. J. 1981. The Journal of Organic Chemistry. 46(16): 3367-3369.
  7. Solubility limitations in the determination of molecular mass distributions of coal liquefaction and hydrocracking products: 1-methyl-2-pyrrolidinone as mobile phase in size exclusion chromatography  |  Herod, A. A., Zhang, S. F., Johnson, B. R., Bartle, K. D., & Kandiyoti, R. 1996. Energy & Fuels. 10(3): 743-750.
  8. Densities, viscosities, speeds of sound, and relative permittivities for water+ cyclic amides (2-pyrrolidinone, 1-methyl-2-pyrrolidinone, and 1-vinyl-2-pyrrolidinone) at different temperatures  |  George, J., & Sastry, N. V. 2004. Journal of Chemical & Engineering Data. 49(2): 235-242.
  9. A Green and Air Pressure Solution Synthesis of CuInSe2 Nanocrystals Using 1-methyl-2-Pyrrolidinone as Hot Solvent  |  Wang, W., **, Z., & Liu, H. 2011. Journal of the American Ceramic Society. 94(8): 2571-2577.

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

1-Methyl-2-pyrrolidinone, 500 ml

sc-237581
500 ml
$77.00

1-Methyl-2-pyrrolidinone, 1 L

sc-237581A
1 L
$112.00