Date published: 2026-4-30

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1-Methyl-1,2,3-triazole (CAS 16681-65-5)

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Alternate Names:
1-Methyl-1H-1,2,3-triazole; 1-Methyl-1H-v-triazole
CAS Number:
16681-65-5
Molecular Weight:
83.09
Molecular Formula:
C3H5N3
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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1-Methyl-1H-1,2,3-triazole finds widespread utilization in scientific research as a versatile reagent for synthesizing diverse organic compounds. Moreover, 1-Methyl-1,2,3-triazole serves as useful in the synthesis of peptide and peptidomimetic compounds, as well as in the production of heterocyclic compounds. This compound holds particular significance as an intermediate in the synthesis of various organic compounds. Its formation arises from the reaction of hydrazines with formaldehyde, facilitated by a base like sodium hydroxide. The reaction progresses through the creation of an intermediate hydrazone, which subsequently undergoes cyclization to yield the desired triazole structure. By offering a versatile and efficient route to a broad range of organic compounds, 1-Methyl-1H-1,2,3-triazole plays a pivotal role in advancing scientific discoveries and applications in multiple fields.


1-Methyl-1,2,3-triazole (CAS 16681-65-5) References

  1. Intermolecular C-C Coupling between 1-Methyl-1,2,3-Triazole and 2,2'-Bipyridine or 1,10-Phenanthroline in MoII Complexes.  |  Fombona, S., et al. 2017. Chemistry. 23: 17870-17873. PMID: 28910507
  2. Strongly Electron-Donating Triazolylidene Ligands: Cationic Metal Carbonyl Complexes of 1-Methyl-1,2,3-triazole as Triazolium Surrogates.  |  Cañadas, P., et al. 2022. Inorg Chem. 61: 1254-1258. PMID: 34990546

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

1-Methyl-1,2,3-triazole, 1 g

sc-484278
1 g
$296.00