1-Linoleoyl Glycerol (CAS 2258-92-6)

1-Linoleoyl Glycerolis a fatty acid glycerol that has been isolated from Saururus chinensis roots. It inhibits PAF-AH with an IC50 of 45 µM. Platelet-activating factor (PAF) is a biologically active phospholipid synthesized by a variety of stimulated cells that acts as a mediator of platelet aggregation, inflammation, and allergy. PAF is converted to the biologically inactive lyso-PAF by the enzyme PAF acetylhydrolase (PAF-AH). Recently, plasma PAF-AH has been linked to atherosclerosis and may be a positive risk factor for coronary heart disease in humans. 1-LG has potential application in cholesterol lowering and antiatherogenic activity.

References

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