1-Linoleoyl Glycerol CAS: 2258-92-6
MF: C21H38O4
MW: 354.52
A fatty acid glycerol that inhibits PAF-AH.

1-Linoleoyl Glycerol (CAS 2258-92-6)

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Alternate Names: 9Z, 12Z-octadecadienoic acid; 1-glyceryl ester; 1-LG
Application: 1-Linoleoyl Glycerol is a fatty acid glycerol that inhibits PAF-AH
CAS Number: 2258-92-6
Molecular Weight: 354.52
Molecular Formula: C21H38O4
Supplemental Information: This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).

1-Linoleoyl Glycerolis a fatty acid glycerol that has been isolated from Saururus chinensis roots. It inhibits PAF-AH with an IC50 of 45 µM. Platelet-activating factor (PAF) is a biologically active phospholipid synthesized by a variety of stimulated cells that acts as a mediator of platelet aggregation, inflammation, and allergy. PAF is converted to the biologically inactive lyso-PAF by the enzyme PAF acetylhydrolase (PAF-AH). Recently, plasma PAF-AH has been linked to atherosclerosis and may be a positive risk factor for coronary heart disease in humans. 1-LG has potential application in cholesterol lowering and antiatherogenic activity.


References

1 Prescott, S.M., Zimmerman, G.A., McIntyre, T.M. Platelet-activating factor. J Biol Chem 265 17381-17384 (1990). 2 Snyder, F. Platelet-activating factor and related acetylated lipids as potent biologically active cellular mediators. Am J Physiol Cell Physiol 259 C697-C708 (1990). 3 Caslake, M.J., Packard, C.J. Lipoprotein-associated phospholipase A2 (platelet-activating factor acetylhydrolase) and cardiovascular disease. Curr Opin Lipidol 14 347-352 (2003). 4 Lee, W.S., Kim, M.J., Beck, Y., et al. Lp-PLA2 inhibitory activities of fatty acid glycerols isolated from Saururus chinensis roots. Biooganic & Medicinal Chemistry Letters 15 3573-3575 (2005).

Formulation :
A solution in acetonitrile
Physical State :
Liquid
Storage :
Store at -80° C
Boiling Point :
84° C
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
Transport :
UN 1648, Class 3, Packing group II
PubChem CID :
6436630
SMILES :
CCCCC/C=C\C/C=C\CCCCCCCC(=O)OC[[email protected]](CO)O

Download SDS (MSDS)

Certificate of Analysis

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Quel est le volume d'ACN dans lequel est dilué le produit, dans le conditionnement sc-220470?

Asked by: RomFC
Merci pour votre question. Veuillez contacter notre Service Technique Thank you for your question regarding the volume of acetonitrile contained in sc-220470. Please contact our Technical Service
Answered by: SCBT Heidelberg Support
Date published: 2018-12-22
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