1-Linoleoyl Glycerolis a fatty acid glycerol that has been isolated from Saururus chinensis roots. It inhibits PAF-AH with an IC50 of 45 µM. Platelet-activating factor (PAF) is a biologically active phospholipid synthesized by a variety of stimulated cells that acts as a mediator of platelet aggregation, inflammation, and allergy. PAF is converted to the biologically inactive lyso-PAF by the enzyme PAF acetylhydrolase (PAF-AH). Recently, plasma PAF-AH has been linked to atherosclerosis and may be a positive risk factor for coronary heart disease in humans. 1-LG has potential application in cholesterol lowering and antiatherogenic activity.
1 Prescott, S.M., Zimmerman, G.A., McIntyre, T.M. Platelet-activating factor. J Biol Chem 265 17381-17384 (1990). 2 Snyder, F. Platelet-activating factor and related acetylated lipids as potent biologically active cellular mediators. Am J Physiol Cell Physiol 259 C697-C708 (1990). 3 Caslake, M.J., Packard, C.J. Lipoprotein-associated phospholipase A2 (platelet-activating factor acetylhydrolase) and cardiovascular disease. Curr Opin Lipidol 14 347-352 (2003). 4 Lee, W.S., Kim, M.J., Beck, Y., et al. Lp-PLA2 inhibitory activities of fatty acid glycerols isolated from Saururus chinensis roots. Biooganic & Medicinal Chemistry Letters 15 3573-3575 (2005).
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