Date published: 2026-4-30

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1-Kestose (CAS 470-69-9)

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Alternate Names:
β-D-Fruf-(2→1)-β-D-Fruf-(2→1)-α-D-Glup
Application:
1-Kestose is a side product of sugar beet raffination
CAS Number:
470-69-9
Purity:
≥98%
Molecular Weight:
504.44
Molecular Formula:
C18H32O16
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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1-Kestose is a carbohydrate compound that functions as a prebiotic in experiment. It acts by selectively promoting the growth and activity of beneficial bacteria in the gut microbiota. 1-Kestose is not digested in the upper gastrointestinal tract, allowing it to reach the colon where it can serve as a substrate for the growth of specific bacterial species. Through this mechanism, 1-Kestose can modulate the composition and metabolic activity of the gut microbiota, potentially leading to various physiological effects. Its role as a prebiotic involves promoting the growth of beneficial bacteria such as Bifidobacteria and Lactobacilli, which are associated with various health benefits. 1-Kestose′s mechanism of action involves targeting and supporting the growth of these beneficial bacterial species, contributing to the balance and diversity of the gut microbiota.


1-Kestose (CAS 470-69-9) References

  1. Exopolysaccharide and kestose production by Lactobacillus sanfranciscensis LTH2590.  |  Korakli, M., et al. 2003. Appl Environ Microbiol. 69: 2073-9. PMID: 12676685
  2. The chromatographic analysis of oligosaccharides and preparation of 1-kestose and nystose in yacon.  |  Zhu, ZY., et al. 2012. Int J Food Sci Nutr. 63: 338-42. PMID: 22013906
  3. Production of the Functional Trisaccharide 1-Kestose from Cane Sugar Molasses Using Aspergillus japonicus β-Fructofuranosidase.  |  Hirabayashi, K., et al. 2017. Curr Microbiol. 74: 145-148. PMID: 27803952
  4. Rapid evaluation of 1-kestose producing β-fructofuranosidases from Aspergillus species and enhancement of 1-kestose production using a PgsA surface-display system.  |  Fujii, T., et al. 2018. Biosci Biotechnol Biochem. 82: 1599-1605. PMID: 29873621
  5. 1-Kestose, the Smallest Fructooligosaccharide Component, Which Efficiently Stimulates Faecalibacterium prausnitzii as Well as Bifidobacteria in Humans.  |  Tochio, T., et al. 2018. Foods. 7: PMID: 30200390
  6. Feeding of 1-Kestose Induces Glutathione-S-Transferase Expression in Mouse Liver.  |  Tochio, T., et al. 2019. Foods. 8: PMID: 30781821
  7. Determining 1-kestose, nystose and raffinose oligosaccharides in grape juices and wines using HPLC: method validation and characterization of products from Northeast Brazil.  |  Dos Santos Lima, M., et al. 2019. J Food Sci Technol. 56: 4575-4584. PMID: 31686689
  8. Experimental Determination of the Threshold Dose for Bifidogenic Activity of Dietary 1-Kestose in Rats.  |  Watanabe, A., et al. 2019. Foods. 9: PMID: 31861709
  9. Activation of butyrate-producing bacteria as well as bifidobacteria in the cat intestinal microbiota by the administration of 1-kestose, the smallest component of fructo-oligosaccharide.  |  Shinohara, M., et al. 2020. J Vet Med Sci. 82: 866-874. PMID: 32389951
  10. 1-Kestose supplementation mitigates the progressive deterioration of glucose metabolism in type 2 diabetes OLETF rats.  |  Watanabe, A., et al. 2020. Sci Rep. 10: 15674. PMID: 32973311
  11. Directionally modulating the product chain length of an inulosucrase by semi-rational engineering for efficient production of 1-kestose.  |  Ni, D., et al. 2022. Enzyme Microb Technol. 160: 110085. PMID: 35752090
  12. 1-Kestose Supplementation Increases Levels of a 5α-Reductase Gene, a Key Isoallolithocholic Acid Biosynthetic Gene, in the Intestinal Microbiota.  |  Fujii, T., et al. 2022. J Nutr Sci Vitaminol (Tokyo). 68: 446-451. PMID: 36310079
  13. Production of 1-kestose in transgenic yeast expressing a fructosyltransferase from Aspergillus foetidus.  |  Rehm, J., et al. 1998. J Bacteriol. 180: 1305-10. PMID: 9495772

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

1-Kestose, 100 mg

sc-255837A
100 mg
$124.00

1-Kestose, 250 mg

sc-255837B
250 mg
$246.00

1-Kestose, 1 g

sc-255837C
1 g
$737.00

1-Kestose, 25 mg

sc-255837
25 mg
$52.00