Date published: 2025-9-25

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1-Hexadecyl Lysophosphatidic Acid (CAS 52603-03-9)

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Alternate Names:
1-Hexadecyl-2-hydroxy-sn-glycero-3-phosphate
Application:
1-Hexadecyl Lysophosphatidic Acid is an ether analog of LPA
CAS Number:
52603-03-9
Purity:
≥98%
Molecular Weight:
396.50
Molecular Formula:
C19H41O6P
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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1-Hexadecyl lysophosphatidic acid (1-HLPA) has been a subject of extensive scientific research due to its diverse mechanisms of action and wide range of applications in various research fields. Investigations have primarily focused on elucidating the roles and functions of this compound. One significant area of research involving 1-HLPA is its involvement in lipid signaling pathways. As a bioactive lipid molecule, 1-HLPA acts as an agonist for specific lysophosphatidic acid (LPA) receptors, triggering intracellular signaling cascades. Researchers have explored the specific signaling mechanisms activated by 1-HLPA, including the activation of downstream effectors such as G-protein-coupled receptors and intracellular signaling molecules. These studies have provided insights into the physiological and pathological implications of 1-HLPA-mediated signaling, including its involvement in cellular processes such as proliferation, migration, and inflammation. Furthermore, 1-HLPA has been utilized in research related to lipid metabolism and lipidomics. Investigations have focused on its impact on lipid homeostasis, lipid transport, and lipid droplet formation. Researchers aim to understand the metabolic fate of 1-HLPA and its interactions with enzymes and transport proteins, thereby deepening our understanding of lipid dynamics and the regulation of lipid-related processes. Moreover, 1-HLPA has found applications in cell biology and tissue engineering research. Its ability to modulate cellular functions makes it a valuable tool for studying cell signaling, migration, and adhesion. Additionally, researchers have explored the incorporation of 1-HLPA into biomaterials for scaffold design and tissue regeneration applications, utilizing its bioactive properties to influence cellular behavior and tissue development.


1-Hexadecyl Lysophosphatidic Acid (CAS 52603-03-9) References

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  2. LPA: a novel lipid mediator with diverse biological actions.  |  Moolenaar, WH. 1994. Trends Cell Biol. 4: 213-9. PMID: 14731680
  3. Different residues mediate recognition of 1-O-oleyllysophosphatidic acid and rosiglitazone in the ligand binding domain of peroxisome proliferator-activated receptor gamma.  |  Tsukahara, T., et al. 2006. J Biol Chem. 281: 3398-407. PMID: 16321982
  4. Toward Understanding Myometrial Regulation: Metabolomic Investigation Reveals New Pathways of Oxytocin and Ritodrine Activity on the Myometrium.  |  Bafor, EE., et al. 2017. Reprod Sci. 24: 691-705. PMID: 27678101
  5. Selective Small Molecule Activators of TREK-2 Channels Stimulate Dorsal Root Ganglion c-Fiber Nociceptor Two-Pore-Domain Potassium Channel Currents and Limit Calcium Influx.  |  Dadi, PK., et al. 2017. ACS Chem Neurosci. 8: 558-568. PMID: 27805811
  6. Liquid Chromatography/Mass Spectrometry Reveals the Effect of Lactobacillus Treatment on the Faecal Metabolite Profile of Rats with Chronic Renal Failure.  |  Wu, B., et al. 2017. Nephron. 135: 156-166. PMID: 27889756
  7. Metabolite accumulation and metabolic network in developing roots of Rehmannia glutinosa reveals its root developmental mechanism and quality.  |  Zhou, Y., et al. 2018. Sci Rep. 8: 14127. PMID: 30237415

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

1-Hexadecyl Lysophosphatidic Acid, 1 mg

sc-204950
1 mg
$63.00

1-Hexadecyl Lysophosphatidic Acid, 5 mg

sc-204950A
5 mg
$286.00