Date published: 2026-4-24

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1-(Diethoxymethyl)imidazole (CAS 61278-81-7)

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CAS Number:
61278-81-7
Molecular Weight:
170.21
Molecular Formula:
C8H14N2O2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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1-(Diethoxymethyl)imidazole is a compound that finds its application primarily in the field of synthetic organic chemistry. It is employed as a reagent for the introduction of protecting groups, where the imidazole moiety can act as a nucleophilic catalyst in the formation of esters and ethers. The diethoxymethyl group makes this compound particularly useful for the protection of alcohols and carboxylic acids, thus enabling selective reactions in multi-step synthetic processes. Moreover, 1-(Diethoxymethyl)imidazole is used in the synthesis of heterocyclic compounds, where the imidazole ring serves as a key structural element. The compound′s role in the preparation of various imidazole derivatives is invaluable for creating molecules with potential applications in material science and as intermediates for more complex chemical entities. Researchers also study the reactivity of this compound to improve the efficiency and selectivity of synthetic pathways that involve imidazole and its derivatives.


1-(Diethoxymethyl)imidazole (CAS 61278-81-7) References

  1. Series of Fluorinated Benzimidazole-Substituted Nitronyl Nitroxides: Synthesis, Structure, Acidity, Redox Properties, and Magnetostructural Correlations.  |  Tretyakov, E., et al. 2022. J Org Chem.. PMID: 36198196
  2. Isoprene-catalysed lithiation: deprotection and functionalisation of imidazole derivatives  |  Rosario Torregrosa,Isidro M. Pastor,Miguel Yus. 2007. Tetrahedron. 947-952.
  3. Lithiation-based and magnesation-based strategies for the functionalization of imidazole: 2001–2010  |  Philip E. Alford. 2012. Metalation of Azoles and Related Five-Membered Ring Heterocycles. 29: 77–102.

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

1-(Diethoxymethyl)imidazole, 10 ml

sc-255753
10 ml
$265.00