Molecular structure of 1-Deoxymannojirimycin hydrochloride, CAS Number: 73465-43-7
1-Deoxymannojirimycin hydrochloride (CAS 73465-43-7)
See product citations (4)
Alternate Names:
Deoxymannojirimycin HCl
Application:
1-Deoxymannojirimycin hydrochloride is a selective inhibitor of α-mannosidases
CAS Number:
73465-43-7
Purity:
≥98%
Molecular Weight:
199.63
Molecular Formula:
C6H13NO4•HCl
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
1-Deoxymannojirimycin hydrochloride is a selective inhibitor of alpha(1rarr2)-mannosidases. Mannosidases are broken into two subtypes: I and II, which display a wide expression pattern. Mannosidase I hydrolyzes (1,2)-linked alpha-D-mannose residues in the oligo-mannose oligosaccharide Man9(GlcNAc)2 and mannosidase II hydrolyzes (1,3)- and (1,6)-linked α-D-mannose residues in Man5(GlcNAc)3. Both mannosidase I and mannosidase II of require a divalent cation cofactor. 1-Deoxymannojirimycin hydrochloride selectively inhibits mannosidase I, but not mannosidase II.
1-Deoxymannojirimycin hydrochloride (CAS 73465-43-7) References
- Structural basis for catalysis and inhibition of N-glycan processing class I alpha 1,2-mannosidases. | Vallee, F., et al. 2000. J Biol Chem. 275: 41287-98. PMID: 10995765
- Structure of Golgi alpha-mannosidase II: a target for inhibition of growth and metastasis of cancer cells. | van den Elsen, JM., et al. 2001. EMBO J. 20: 3008-17. PMID: 11406577
- An Oxidative Mannich Cyclization Methodology for the Stereocontrolled Synthesis of Highly Functionalized Piperidines. | Wu, XD., et al. 1998. J Org Chem. 63: 841-859. PMID: 11672082
- DC-SIGN and L-SIGN are high affinity binding receptors for hepatitis C virus glycoprotein E2. | Lozach, PY., et al. 2003. J Biol Chem. 278: 20358-66. PMID: 12609975
- The C type lectins DC-SIGN and L-SIGN: receptors for viral glycoproteins. | Lozach, PY., et al. 2007. Methods Mol Biol. 379: 51-68. PMID: 17502670
- Replication-competent recombinant vesicular stomatitis virus encoding hepatitis C virus envelope proteins. | Tani, H., et al. 2007. J Virol. 81: 8601-12. PMID: 17553880
- Expression of a full-length cDNA coding for human intestinal lactase-phlorizin hydrolase reveals an uncleaved, enzymatically active, and transport-competent protein. | Naim, HY., et al. 1991. J Biol Chem. 266: 12313-20. PMID: 1905719
- Hiding inside? Intracellular expression of non-glycosylated c-kit protein in cardiac progenitor cells. | Shi, H., et al. 2016. Stem Cell Res. 16: 795-806. PMID: 27161312
- Inhibitors of the biosynthesis and processing of N-linked oligosaccharide chains. | Elbein, AD. 1987. Annu Rev Biochem. 56: 497-534. PMID: 3304143
- Retrofusion of intralumenal MVB membranes parallels viral infection and coexists with exosome release. | Perrin, P., et al. 2021. Curr Biol. 31: 3884-3893.e4. PMID: 34237268
- A role for N-glycosylation in active adenosine deaminase 2 production. | Ito, M., et al. 2022. Biochim Biophys Acta Gen Subj. 1866: 130237. PMID: 36029899
- 1-Deoxymannojirimycin is a non-competitive inhibitor of mannosidase II. | Slusarewicz, P. and Warren, G. 1995. Glycobiology. 5: 154-5. PMID: 7780187
- Glycosylation of native MHC class Ia molecules is required for recognition by allogeneic cytotoxic T lymphocytes. | Bagriaçik, EU., et al. 1996. Glycobiology. 6: 413-21. PMID: 8842705
- Studies on the site and mechanism of attachment of phosphorylcholine to a filarial nematode secreted glycoprotein. | Houston, KM., et al. 1997. J Biol Chem. 272: 1527-33. PMID: 8999824
- Substrate specificities of recombinant murine Golgi alpha1, 2-mannosidases IA and IB and comparison with endoplasmic reticulum and Golgi processing alpha1,2-mannosidases. | Lal, A., et al. 1998. Glycobiology. 8: 981-95. PMID: 9719679
Inhibitor of:
alpha-mannosidase.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
1-Deoxymannojirimycin hydrochloride, 1 mg | sc-255823 | 1 mg | $87.00 | |||
1-Deoxymannojirimycin hydrochloride, 5 mg | sc-255823A | 5 mg | $143.00 |