Date published: 2026-3-7

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1-Cyclohexylpiperazine (CAS 17766-28-8)

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CAS Number:
17766-28-8
Molecular Weight:
168.28
Molecular Formula:
C10H20N2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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1-Cyclohexylpiperazine (1-CHP) is a valuable organic compound widely employed in scientific research and the synthesis of numerous drugs. Its versatility as a chemical intermediate allows for the creation of various essential compounds, such as neurotransmitters and hormones. Structurally, 1-Cyclohexylpiperazine is a cyclic amine, featuring a piperazine ring that resembles cyclohexanone. This stable ring structure, with limited solubility in water, makes it an ideal starting material for diverse compound syntheses. In the realm of scientific investigation, 1-Cyclohexylpiperazine serves as a foundation for the development of various compounds, including those vital neurotransmitters and hormones. 1-Cyclohexylpiperazine is also harnessed in the synthesis of polymers and other materials. Its cyclic amine structure, centered around the piperazine ring, is considered pivotal in its mechanism of action. Researchers propose that the piperazine ring of 1-Cyclohexylpiperazine binds with receptor sites in diverse compounds, facilitating interactions with their target receptors. With its wide-ranging applications and promising properties, 1-Cyclohexylpiperazine continues to be a prominent player in the world of organic chemistry and drug development.


1-Cyclohexylpiperazine (CAS 17766-28-8) References

  1. 4-(tetralin-1-yl)- and 4-(naphthalen-1-yl)alkyl derivatives of 1-cyclohexylpiperazine as sigma receptor ligands with agonist sigma2 activity.  |  Berardi, F., et al. 2004. J Med Chem. 47: 2308-17. PMID: 15084129
  2. Preparation of 99mTc-nitrido asymmetrical heterocomplex with 4-(cyclohexylpiperazin-1-yl)-dithioformate and its biological evaluation as a potential myocardial imaging agent.  |  Lu, J., et al. 2007. Appl Radiat Isot. 65: 1134-9. PMID: 17616466
  3. Complete experimental and theoretical proton and carbon nuclear magnetic resonance spectral assignments, molecular structure and conformational study of 1-cyclohexylpiperazine and 1-(4-pyridyl)piperazine.  |  Alver, O. 2010. Magn Reson Chem. 48: 53-60. PMID: 19890942
  4. 1-Cyclohexylpiperazine and 3,3-dimethylpiperidine derivatives as sigma-1 (sigma1) and sigma-2 (sigma2) receptor ligands: a review.  |  Berardi, F., et al. 2009. Cent Nerv Syst Agents Med Chem. 9: 205-19. PMID: 20021355

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

1-Cyclohexylpiperazine, 5 g

sc-224635
5 g
$47.00