1-Benzyl-5-oxopyrrolidine-3-carboxylic acid (CAS 5733-86-8)
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1-Benzyl-5-oxopyrrolidine-3-carboxylic acid primarily serves as a fundamental starting material in the synthesis of diverse pharmaceuticals and agrochemicals. Notably, this compound has been extensively employed in the synthesis of an array of peptide-based drugs, spanning dipeptides, tripeptides, and tetrapeptides. Additionally, it finds utility in synthesizing various heterocyclic compounds like quinolines and isoquinolines. Furthermore, 1-Benzyl-5-oxopyrrolidine-3-carboxylic acid plays a vital role in creating peptide-based prodrugs and inhibitors targeting enzymes such as proteases and kinases. It is believed that this compound acts as a proton donor, facilitating the formation of peptide bonds between amino acids. Moreover, it may serve as an acid catalyst, aiding in the peptide bond formation process between amino acids.
1-Benzyl-5-oxopyrrolidine-3-carboxylic acid (CAS 5733-86-8) References
- Inhibitors of human neutrophil elastase based on a highly functionalized N-amino-4-imidazolidinone scaffold. | He, G., et al. 2010. Eur J Med Chem. 45: 4280-7. PMID: 20638756
- Analgesic and Anticancer Activity of Benzoxazole Clubbed 2-Pyrrolidinones as Novel Inhibitors of Monoacylglycerol Lipase. | Afzal, O., et al. 2021. Molecules. 26: PMID: 33924091
- Discovery and Characterization of the First Nonpeptide Antagonists for the Relaxin-3/RXFP3 System. | Gay, EA., et al. 2022. J Med Chem. 65: 7959-7974. PMID: 35594150
- Synthesis, docking, and biological evaluation of novel 1-benzyl-4-(4-(R)-5-sulfonylidene-4,5-dihydro-1H-1,2,4-triazol-3-yl)pyrrolidin-2-ones as potential nootropic agents. | Semenets, AP., et al. 2022. Eur J Med Chem. 244: 114823. PMID: 36274278
- Synthesis and structure-activity relationships of 7-[3-(1-aminoalkyl)pyrrolidinyl]- and 7-[3-1-aminocycloalkyl)pyrrolidinyl]-quinolone antibacterials. | Kimura, Y., et al. 1994. Chem Pharm Bull (Tokyo). 42: 1442-54. PMID: 7923467
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
1-Benzyl-5-oxopyrrolidine-3-carboxylic acid, 250 mg | sc-258644 | 250 mg | $92.00 | |||
1-Benzyl-5-oxopyrrolidine-3-carboxylic acid, 1 g | sc-258644A | 1 g | $214.00 |