1-Azakenpaullone (CAS 676596-65-9)

1-Azakenpaullone is a synthetic molecule classified as a paullone derivative, which is part of a broader category of compounds known as kenpaullones. These compounds are notable for their ability to inhibit cyclin-dependent kinases (CDKs), with a particular emphasis on CDK1, CDK2, CDK5, and glycogen synthase kinase 3 beta (GSK-3β). As an inhibitor, 1-Azakenpaullone exhibits strong selectivity and potency, making it a useful tool in the study of cell cycle regulation and neuronal signaling pathways. The mechanism of action of 1-Azakenpaullone involves the competitive inhibition of ATP binding sites on the target kinases. This inhibition alters the phosphorylation status of various substrates involved in critical signaling pathways that govern cellular processes such as cell division, differentiation, and apoptosis. Specifically, its inhibition of GSK-3β is of particular interest in research focused on neurodegenerative diseases and neural development, as GSK-3β is a key player in neuronal cell function and structure.