Molecular structure of 1-Amino-2-hydroxyguanidine, p-Toluenesulfonate
1-Amino-2-hydroxyguanidine, p-Toluenesulfonate
See product citations (1)
Application:
1-Amino-2-hydroxyguanidine, p-Toluenesulfonate is a potent inhibitor of NOS2 (iNOS)
Purity:
≥95%
Molecular Weight:
262.3
Molecular Formula:
C8H14N4O4S
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
1-Amino-2-hydroxyguanidine, p-Toluenesulfonate is a potent cell-permeable inhibitor of NOS2 (inducible nitric oxide synthase; iNOS), in mouse macrophages (IC50 = 68 µM) and in vitro rat aortic smooth muscle cells (RASM) (IC50 = 114 μM).
1-Amino-2-hydroxyguanidine, p-Toluenesulfonate References
- Attenuation of endotoxin-induced multiple organ dysfunction by 1-amino-2-hydroxy-guanidine, a potent inhibitor of inducible nitric oxide synthase. | Ruetten, H., et al. 1996. Br J Pharmacol. 118: 261-70. PMID: 8735625
- Inactivation of nitric oxide synthase by substituted aminoguanidines and aminoisothioureas. | Wolff, DJ., et al. 1997. J Pharmacol Exp Ther. 283: 265-73. PMID: 9336332
Inhibitor of:
NOS2.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
1-Amino-2-hydroxyguanidine, p-Toluenesulfonate, 10 mg | sc-3565 | 10 mg | $200.00 |