Molecular structure of 1-Amino-2,5-anhydro-1-deoxy-D-mannitol, CAS Number: 228862-97-3
1-Amino-2,5-anhydro-1-deoxy-D-mannitol (CAS 228862-97-3)
Application:
1-Amino-2,5-anhydro-1-deoxy-D-mannitol is a β-D-fructose analog
CAS Number:
228862-97-3
Molecular Weight:
163.17
Molecular Formula:
C6H13NO4
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
1-Amino-2,5-anhydro-1-deoxy-D-mannitol (1-AADM) is a beta-D-fructose analog. It serves as a substrate for the hexose transporter of Trypanosoma brucei, while the human erythrocyte transporter can only use D-glucose. It has been used as a fluorescent probe for the detection of carbohydrates and as an inhibitor of glycosidases. 1-Amino-2,5-anhydro-1-deoxy-D-mannitol has also been utilized to study the structure and function of enzymes and cell membranes. Moreover, it has been observed to interact with cell receptors, thereby resulting in alterations in the signaling pathways of cells.
1-Amino-2,5-anhydro-1-deoxy-D-mannitol (CAS 228862-97-3) References
- An easy stereospecific synthesis of 1-amino-2,5-anhydro-1-deoxy-D-mannitol and arylamino derivatives. | Claustre, S., et al. 1999. Carbohydr Res. 315: 339-44. PMID: 10399304
- Ethambutol-sugar hybrids as potential inhibitors of mycobacterial cell-wall biosynthesis. | Reynolds, RC., et al. 1999. Carbohydr Res. 317: 164-79. PMID: 10466213
- Glycolysis as a target for the design of new anti-trypanosome drugs. | Verlinde, CL., et al. 2001. Drug Resist Updat. 4: 50-65. PMID: 11512153
- Development of high-affinity ligands and photoaffinity labels for the D-fructose transporter GLUT5. | Yang, J., et al. 2002. Biochem J. 367: 533-9. PMID: 12119043
- Exploring the Substrate Specificity of a Sugar Transporter with Biosensors and Cheminformatics. | Park, J., et al. 2023. ACS Synth Biol. 12: 565-571. PMID: 36719856
- The Arabidopsis SWEET1 and SWEET2 uniporters recognize similar substrates while differing in subcellular localization. | Gwon, S., et al. 2023. J Biol Chem. 299: 105389. PMID: 37890779
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Enzyme.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
1-Amino-2,5-anhydro-1-deoxy-D-mannitol, 10 mg | sc-220459 | 10 mg | $320.00 |