1-Alaninechlamydocin (CAS 141446-96-0)
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1-Alaninechlamydocin is a fungal metabolite renowned for its role as an inhibitor of histone deacetylases (HDACs). Its potent ability to reduce overall HDAC activity in HeLa cell lysates is concentration-dependent. Notably, the compound effectively suppresses the proliferation of various cell types, including MIA PaCa-2, PANC-1, and hTERT-HPNE cells, with GI50 values of 5.3, 14, and 2.0 nM, respectively. In particular, 1-Alaninechlamydocin stands out as a remarkable HDAC inhibitor, exerting significant influence on cellular processes. Its impact encompasses inducing G2/M cell cycle arrest and promoting apoptosis specifically in MIA PaCa-2 cells. Furthermore, even at remarkably low concentrations as low as 2 nM, it effectively hampers the activity of SE, further solidifying its potency as an HDAC inhibitor.
1-Alaninechlamydocin (CAS 141446-96-0) References
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Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
1-Alaninechlamydocin, 500 µg | sc-391717 | 500 µg | $204.00 |