1-Acyl-PAF is the predominant PAF species produced by stimulated endothelial cells1,2. This compound induces IL-6 release in rat anterior pituitary cells in vitro and the compound also displays protective effects in oxidative stress.
1. Mueller, H.W., et al. 1991. Biochem. Biophys. Res. Commun. 176: 1557-1564. PMID: 2039529
2. Whatley, R.E., et al. 1992. Prostaglandins 43: 21-29. PMID: 1546171
3. Spangelo, B.L., et al. 1996. Endocrinology. 137: 4419-4426. PMID: 8828503
4. Balestrieri, M.L., et al. 2003. J. Lipid Res. 44: 380-387. PMID: 12576520
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