Date published: 2026-4-28

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1,8-Naphthalenediol (CAS 569-42-6)

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Alternate Names:
Naphthalene-1,8-diol; 1,8-Dihydroxynaphthalene
CAS Number:
569-42-6
Purity:
≥97%
Molecular Weight:
160.17
Molecular Formula:
C10H8O2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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1,8-Naphthalenediol (ND) is an organic compound which is insoluble in water but dissolvable in various organic solvents. It has been a staple in the production of dyes, plastics, and has seen use as a preservative in certain food items, as well as a component in perfumes. In scientific research, 1,8-Naphthalenediol′s versatility is highlighted through its role as a reagent in chemical syntheses and as an agent in biochemical and physiological studies. Its application extends to exploring enzyme kinetics, protein-ligand interactions, and the metabolism of drugs. 1,8-Naphthalenediol acts by inhibiting specific enzymes, including the cytochrome P450 enzymes, which play a significant part in the metabolic process of various substances, thereby influencing their biochemical and physiological behaviors. This property of 1,8-Naphthalenediol also makes it valuable in the study of the impact of environmental pollutants on health.


1,8-Naphthalenediol (CAS 569-42-6) References

  1. Naphthalene diols: a new class of antioxidants intramolecular hydrogen bonding in catechols, naphthalene diols, and their aryloxyl radicals.  |  Foti, MC., et al. 2002. J Org Chem. 67: 5190-6. PMID: 12126405
  2. Ferromagnetic coupling by orthogonal magnetic orbitals in a heterodinuclear CuIIVIV=O complex and in a homodinuclear CuIICuII complex.  |  Glaser, T., et al. 2006. Inorg Chem. 45: 4889-91. PMID: 16780307
  3. A trinucleating ligand based on 1,8-naphthalenediol: synthesis, structural and magnetic properties of a linear Cu(II)Cu(II)Cu(II) complex.  |  Glaser, T., et al. 2007. Chem Commun (Camb). 356-8. PMID: 17220969
  4. Structures and magnetic properties of dysprosium complexes: the effect of crystallization temperature.  |  Guo, M., et al. 2017. Dalton Trans. 46: 564-570. PMID: 27977026
  5. Characterization and Fate of Hydrogen-Bonded Free-Radical Intermediates and Their Coupling Products from the Hydrogen Atom Transfer Agent 1,8-Naphthalenediol.  |  Manini, P., et al. 2018. ACS Omega. 3: 3918-3927. PMID: 31458630
  6. Boronic, diboronic and boric acid esters of 1,8-naphthalenediol - synthesis, structure and formation of boronium salts.  |  Manankandayalage, CP., et al. 2020. Dalton Trans. 49: 4834-4842. PMID: 32215427
  7. Proof of Phosphate Diester Binding Ability of Cytotoxic DNA-Binding Complexes.  |  Simon, J., et al. 2020. Inorg Chem. 59: 14615-14619. PMID: 32975115
  8. Evaluation of the binding mode of a cytotoxic dinuclear nickel complex to two neighboring phosphates of the DNA backbone.  |  Simon, J., et al. 2022. Dalton Trans. 51: 2863-2875. PMID: 35098951
  9. Ring-hydroxylated propranolol: synthesis and beta-receptor antagonist and vasodilating activities of the seven isomers.  |  Oatis, JE., et al. 1981. J Med Chem. 24: 309-14. PMID: 6115057

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

1,8-Naphthalenediol, 10 g

sc-334249
10 g
$394.00