Molecular structure of 1,7-Phenanthroline, CAS Number: 230-46-6
1,7-Phenanthroline (CAS 230-46-6)
Application:
1,7-Phenanthroline is an inhibitor of germination and growth of plants
CAS Number:
230-46-6
Molecular Weight:
180.21
Molecular Formula:
C12H8N2
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
1,7-Phenanthroline is a phenanthrene aza-analog. In the presence of a rat liver S9 fraction, 1,7-Phenanthroline was found to be mutagenic in the Ames test using Salmonella typhimurium TA100. In vitro, it has shown to be an effective inhibitor of polymerase chain reaction. It is also used as a chelating agent, making it useful for various scientific applications.
1,7-Phenanthroline (CAS 230-46-6) References
- Early events in the induction of rat hepatic UDP-glucuronosyltransferases, glutathione S-transferase, and microsomal epoxide hydrolase by 1,7-phenanthroline: comparison with oltipraz, tert-butyl-4-hydroxyanisole, and tert-butylhydroquinone. | Lamb, JG. and Franklin, MR. 2000. Drug Metab Dispos. 28: 1018-23. PMID: 10950843
- [Anti-carcinogenic structural modification by fluorine-substitution in aza-polycyclic aromatic hydrocarbons]. | Saeki, K. 2000. Yakugaku Zasshi. 120: 1373-85. PMID: 11193386
- Induction of hepatic phase II drug-metabolizing enzymes by 1,7-phenanthroline in rats is accompanied by induction of MRP3. | Wang, S., et al. 2003. Drug Metab Dispos. 31: 773-5. PMID: 12756211
- 1,10-Phenanthroline phosphorylates (activates) MAP kinase in Xenopus oocytes. | Watanabe, K., et al. 2003. Cell Signal. 15: 1139-47. PMID: 14575869
- In vivo mutagenicity of benzo[f]quinoline, benzo[h]quinoline, and 1,7-phenanthroline using the lacZ transgenic mice. | Yamada, K., et al. 2004. Mutat Res. 559: 83-95. PMID: 15066577
- L-histidinol dehydrogenase, a Zn2+-metalloenzyme. | Grubmeyer, C., et al. 1989. Arch Biochem Biophys. 272: 311-7. PMID: 2665648
- Mononuclear silver(I) complexes with 1,7-phenanthroline as potent inhibitors of Candida growth. | Savić, ND., et al. 2018. Eur J Med Chem. 156: 760-773. PMID: 30053719
- Design, Synthesis, Molecular Modelling and Anticancer Activities of New Fused Phenanthrolines. | Al Matarneh, CM., et al. 2020. Molecules. 25: PMID: 31991806
- Comparative effects of 1,10-phenanthroline and 1,7-phenanthroline on DNA and RNA synthesis in mouse spleen. | Chang, CH. and Yarbro, JW. 1978. Life Sci. 22: 1007-10. PMID: 642706
- The effects of 1,10-phenanthroline on the binding of activated rat hepatic glucocorticoid-receptor complexes to deoxyribonucleic acid-cellulose. | Schmidt, TJ., et al. 1981. Endocrinology. 109: 803-12. PMID: 7262022
- 1,10-Phenanthroline increases nuclear accumulation of insulin in response to inhibiting insulin degradation but has a biphasic effect on insulin's ability to increase mRNA levels. | Harada, S., et al. 1994. DNA Cell Biol. 13: 487-93. PMID: 8024692
- Effect of 1,10-phenanthroline on DNA binding by 1,25-(OH)2 vitamin D receptor. | Atkins, KB. and Beitz, DC. 1995. Horm Metab Res. 27: 455-60. PMID: 8575724
- Phase II-selective induction of hepatic drug-metabolizing enzymes by oltipraz -5-(2-pyrazinyl)-4-methyl-1,2-dithiol-3-thione-, 1,7-phenanthroline, and 2,2'-dipyridyl in rats is not accompanied by induction of intestinal enzymes. | Vargas, M., et al. 1998. Drug Metab Dispos. 26: 91-7. PMID: 9456293
- Drug-metabolizing enzyme induction by 2,2'-dipyridyl, 1,7-phenanthroline, 7,8-benzoquinoline and oltipraz in mouse. | Carr, BA. and Franklin, MR. 1998. Xenobiotica. 28: 949-56. PMID: 9849642
- Induction of drug metabolizing enzymes by 1,7-phenanthroline and oltipraz in mice is unrelated to Ah-responsiveness. | Carr, BA. and Franklin, MR. 1999. J Biochem Mol Toxicol. 13: 77-82. PMID: 9890192
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
1,7-Phenanthroline, 1 g | sc-223117 | 1 g | $70.00 |