Molecular structure of 1,7-Dimethylxanthine-d6 (dimethyl-d6), CAS Number: 611-59-6 (unlabeled)
1,7-Dimethylxanthine-d6 (dimethyl-d6) (CAS 611-59-6 (unlabeled))
Alternate Names:
1,7-Dimethyl-1H-purine-2,6-dione-(dimethyl-d6)
Application:
1,7-Dimethylxanthine-d6 (dimethyl-d6) is a labeled derivative of xanthine
CAS Number:
611-59-6 (unlabeled)
Purity:
98 atom % D, 98% (CP)
Molecular Weight:
186.20
Molecular Formula:
C7D6H2N4O2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
1,7-Dimethylxanthine-d6 (dimethyl-d6) is a labeled form of 1,7-Dimethylxanthine also known as Paraxanthine (sc-212526), which functions as a PARP-1 inhibitor in pulmonary epithelial cells. It is known that 1,7-Dimethylxanthine-d6 (dimethyl-d6) is structurally similar to caffeine (sc-202514) and possibly mediates the physiological effects of caffeine. Studies suggest that 1,7-Dimethylxanthine-d6 (dimethyl-d6) acts as a competitive phosphodiesterase inhibitor, which increases intracellular cAMP, activates PKA, inhibits TNF-α and leukotriene synthesis. Also 1,7-Dimethylxanthine-d6 (dimethyl-d6) acts as a Na+/K+ ATPase enzymatic effector.
1,7-Dimethylxanthine-d6 (dimethyl-d6) (CAS 611-59-6 (unlabeled)) References
- Cyclic nucleotide phosphodiesterases. | Essayan, DM. 2001. J Allergy Clin Immunol. 108: 671-80. PMID: 11692087
- Paraxanthine, the primary metabolite of caffeine, provides protection against dopaminergic cell death via stimulation of ryanodine receptor channels. | Guerreiro, S., et al. 2008. Mol Pharmacol. 74: 980-9. PMID: 18621927
- Inhibition of acute pulmonary and systemic inflammation by 1,7-dimethylxanthine. | Geraets, L., et al. 2010. Eur J Pharmacol. 629: 132-9. PMID: 19962977
- Isolation of lipolytic substances caffeine and 1,7-dimethylxanthine from the stem and rhizome of Sinomenium actum. | Jiang, M., et al. 1998. Planta Med. 64: 375-7. PMID: 9619123
- Pentoxifylline inhibits TNF-alpha production from human alveolar macrophages. | Marques, LJ., et al. 1999. Am J Respir Crit Care Med. 159: 508-11. PMID: 9927365
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
1,7-Dimethylxanthine-d6 (dimethyl-d6), 2 mg | sc-297967 | 2 mg | $443.00 |