Date published: 2025-12-8

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1,7-Diaza-12-crown-4 (CAS 294-92-8)

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Alternate Names:
1,7-Dioxa-4,10-diazacyclododecane
CAS Number:
294-92-8
Molecular Weight:
174.24
Molecular Formula:
C8H18N2O2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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1,7-Diaza-12-crown-4 is a complexing agent in various experimental applications. It has the ability to selectively bind to metal ions, particularly alkali and alkaline earth metal ions, due to its crown ether structure. 1,7-Diaza-12-Crown-4 forms stable complexes with metal ions, which can be utilized in various chemical and biochemical processes. In experimental applications, 1,7-Diaza-12-crown-4 is used to facilitate the extraction and separation of metal ions from aqueous solutions, as well as in the synthesis of coordination compounds. Its mechanism of action involves the formation of coordination complexes with metal ions, leading to the enhancement of certain chemical reactions or the isolation of specific metal ions from complex mixtures.


1,7-Diaza-12-crown-4 (CAS 294-92-8) References

  1. Lanthanide complexes based on a 1,7-diaza-12-crown-4 platform containing picolinate pendants: a new structural entry for the design of magnetic resonance imaging contrast agents.  |  Mato-Iglesias, M., et al. 2008. Inorg Chem. 47: 7840-51. PMID: 18672876
  2. Complexation and fluorescence behavior of diazacrown ether carrying two anthryl pendants.  |  Kubo, K., et al. 1999. Talanta. 49: 339-44. PMID: 18967605
  3. Stability, water exchange, and anion binding studies on lanthanide(III) complexes with a macrocyclic ligand based on 1,7-diaza-12-crown-4: extremely fast water exchange on the Gd3+ complex.  |  Pálinkás, Z., et al. 2009. Inorg Chem. 48: 8878-89. PMID: 19655713
  4. Macrocyclic Receptor Showing Improved PbII/ZnII and PbII/CaII Selectivities  |  Raquel Ferreirós-Martínez, Carlos Platas-Iglesias, Andrés de Blas, David Esteban-Gómez, Teresa Rodríguez-Blas. 2010. European Journal of Inorganic Chemistry. 2010: 2495-2503.
  5. Solid state and solution structures of alkaline-earth complexes with lariat ethers containing aniline and benzimidazole pendants  |  Aurora Rodríguez-Rodríguez, Israel Carreira-Barral, Martín Regueiro-Figueroa, David Esteban-Gómez, Carlos Platas-Iglesias, Andrés de Blas, Teresa Rodríguez-Blas. 2012. Polyhedron. 31: 402-412.

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

1,7-Diaza-12-crown-4, 100 mg

sc-223113
100 mg
$122.00