1,5-Isoquinolinediol (CAS 5154-02-9)
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1,5-Isoquinolinediol is a small molecule with cell protective and neuroprotective properties. 1,5-isopuinolinediol is an inhibitor of both PARP-1 (poly (ADP-ribose) polymerase-1) and NOS2 (inducible nitric oxide synthase). PARP and NOS2 activations are implicated in deleterious inflammatory responses and suppression of their activity by 1,5 isoquinolinediol has been correlated to cellular protection and survival. The DNA excision-repair enzyme PARP (poly (ADP-ribose) synthetase, PARS) is activated by free radical oxidative cleavage of the DNA backbone, and excessive PARS activation leads to deplation of cellular NAD and ATP, progressing to cell death. A study demonstrates taht 1,5-isoquinolinediol protects against the neurotoxicity generated by NO-induced PARS activation and by NMDA in rat brain neurons. The Inhibition of PARP by 1,5-isoquinolinediol has also been correlated to a decrease in illegitimate recombination in gene targeting techniques, increasing the efficiency of specific alterations to chromosomal DNA.
1,5-Isoquinolinediol (CAS 5154-02-9) References
- Poly(ADP-ribose) polymerase inhibition in oxidant-stressed endothelial cells prevents oncosis and permits caspase activation and apoptosis. | Walisser, JA. and Thies, RL. 1999. Exp Cell Res. 251: 401-13. PMID: 10471325
- Inhibition of poly(ADP-ribose)polymerase stimulates extrachromosomal homologous recombination in mouse Ltk-fibroblasts. | Semionov, A., et al. 1999. Nucleic Acids Res. 27: 4526-31. PMID: 10536164
- Poly(ADP-ribose) polymerase-1 is a positive regulator of the p53-mediated G1 arrest response following ionizing radiation. | Wieler, S., et al. 2003. J Biol Chem. 278: 18914-21. PMID: 12642583
- 1,5-isoquinolinediol increases the frequency of gene targeting by homologous recombination in mouse fibroblasts. | Semionov, A., et al. 2003. Biochem Cell Biol. 81: 17-24. PMID: 12683632
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- Caspase-1 and poly (ADP-ribose) polymerase inhibitors may protect against peroxynitrite-induced neurotoxicity independent of their enzyme inhibitor activity. | Zhang, Y. and Rosenberg, PA. 2004. Eur J Neurosci. 20: 1727-36. PMID: 15379993
- Neuroprotective effect of peroxynitrite decomposition catalyst and poly(adenosine diphosphate-ribose) polymerase inhibitor alone and in combination in rats with focal cerebral ischemia. | Sharma, SS., et al. 2004. J Neurosurg. 101: 669-75. PMID: 15481724
- Mitochondrial impairment induced by poly(ADP-ribose) polymerase-1 activation in cortical neurons after oxygen and glucose deprivation. | Tanaka, S., et al. 2005. J Neurochem. 95: 179-90. PMID: 16181422
- Inhibition of NOS-2 induction in LPS-stimulated J774.2 cells by 1, 5-isoquinolinediol, an inhibitor of PARP. | Olszanecki, R., et al. 2006. J Physiol Pharmacol. 57: 109-17. PMID: 16601319
- PARP inhibition reduces acute colonic inflammation in rats. | Sánchez-Fidalgo, S., et al. 2007. Eur J Pharmacol. 563: 216-23. PMID: 17374531
- Nitric oxide activation of poly(ADP-ribose) synthetase in neurotoxicity. | Zhang, J., et al. 1994. Science. 263: 687-9. PMID: 8080500
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Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
1,5-Isoquinolinediol, 20 mg | sc-200127 | 20 mg | $57.00 | |||
1,5-Isoquinolinediol, 100 mg | sc-200127A | 100 mg | $237.00 |