1,5-Dicaffeoylquinic acid (CAS 19870-46-3)
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1,5-Dicaffeoylquinic acid (1,5-DCQA) has been found in A. montana and is an HIV-1 integrase inhibitor and free radical scavenger. 1,5-Dicaffeoylquinic acid inhibits HIV-1 integrase 3′ end processing, end joining, and disintegration with IC50 values of 0.35, 0.56, and 0.84 μg/ml, respectively. It also inhibits HIV-1 replication in MT-2 T lymphoblastoid cells with an ED50 value of 2 μg/ml. 1,5-Dicaffeoylquinic acid (0.25-1 μM) reduces the level of free radicals released from human polymorphonuclear (PMN) cells stimulated by N-formyl-Met-Leu-Phe (fMLP Item No. sc-358988) in a dose-dependent manner. It also dose-dependently increases cell survival and glutathione (GSH) levels and decreases reactive oxygen species (ROS) production and lactate dehydrogenase (LDH) release in an oxygen-glucose deprivation/reperfusion assay in rat cerebral astrocytes when used at concentrations ranging from 5 to 100 µM.
1,5-Dicaffeoylquinic acid (CAS 19870-46-3) References
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Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
1,5-Dicaffeoylquinic acid, 10 mg | sc-506021 | 10 mg | $255.00 |