Molecular structure of 1,4-PB-ITU dihydrobromide, CAS Number: 157254-60-9
1,4-PB-ITU dihydrobromide (CAS 157254-60-9)
Alternate Names:
S,S′-1,4-phenylene-bis(1,2-ethanediyl)bis-isothiourea, dihydrobromide
Application:
1,4-PB-ITU dihydrobromide is a potent inhibitor of NOS
CAS Number:
157254-60-9
Purity:
>97%
Molecular Weight:
444.2
Molecular Formula:
C12H18N4S2•2HBr
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
1,4-PB-ITU dihydrobromide is a potent inhibitor of purified human NOS2 (iNOS) and NOS1 (nNOS) with Ki values of 7.4 and 16 nM, respectively, compared to a Ki of 360 nM for human NOS3 (eNOS). 1,4-PB-ITU inhibition in whole cells is greatly diminished, presumably to poor membrane permeability.
1,4-PB-ITU dihydrobromide (CAS 157254-60-9) References
- Potent and selective inhibition of human nitric oxide synthases. Inhibition by non-amino acid isothioureas. | Garvey, EP., et al. 1994. J Biol Chem. 269: 26669-76. PMID: 7523409
Inhibitor of:
NOS1, NOS2, and NOS3.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
1,4-PB-ITU dihydrobromide, 10 mg | sc-202003 | 10 mg | $20.00 | |||
1,4-PB-ITU dihydrobromide, 50 mg | sc-202003A | 50 mg | $58.00 |