Molecular structure of 1,4-DPCA, CAS Number: 331830-20-7
1,4-DPCA (CAS 331830-20-7)
See product citations (5)
Alternate Names:
1,4-dihydrophenonthrolin-4-one-3-Carboxylic acid
Application:
1,4-DPCA is a selective and potent inhibitor of P4HA (α-prolyl 4-hydroxylase)
CAS Number:
331830-20-7
Molecular Weight:
240.21
Molecular Formula:
C13H8N2O3
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
1,4 DPCA is a selective and potent inhibitor of prolyl 4-hydroxylation (P4H) in vitro. It may act to Inhibit P4HA (alpha-prolyl 4-hydroxylase), an oxygen-sensing enzyme that targets the pro-angiogenic factor HIF-1alpha for destruction upon hydroxylation of a specific proline residue. 1,4-DPCA has also been shown to inhibit asparaginyl-hydroxylase factor inhibiting HIF (FIH) and to be useful for controlling excess collagen deposition in pathological fibrosis. 1,4-DPCA is an activator of HIF-1 alpha.
1,4-DPCA (CAS 331830-20-7) References
- Inhibition of prolyl 4-hydroxylase in vitro and in vivo by members of a novel series of phenanthrolinones. | Franklin, TJ., et al. 2001. Biochem J. 353: 333-8. PMID: 11139398
- Targeting of HIF-alpha to the von Hippel-Lindau ubiquitylation complex by O2-regulated prolyl hydroxylation. | Jaakkola, P., et al. 2001. Science. 292: 468-72. PMID: 11292861
- The inhibition of factor inhibiting hypoxia-inducible factor (FIH) by beta-oxocarboxylic acids. | Banerji, B., et al. 2005. Chem Commun (Camb). 5438-40. PMID: 16261239
- Autophagy in cancer associated fibroblasts promotes tumor cell survival: Role of hypoxia, HIF1 induction and NFκB activation in the tumor stromal microenvironment. | Martinez-Outschoorn, UE., et al. 2010. Cell Cycle. 9: 3515-33. PMID: 20855962
- VEGF secreted by hypoxic Müller cells induces MMP-2 expression and activity in endothelial cells to promote retinal neovascularization in proliferative diabetic retinopathy. | Rodrigues, M., et al. 2013. Diabetes. 62: 3863-73. PMID: 23884892
- Drug-induced regeneration in adult mice. | Zhang, Y., et al. 2015. Sci Transl Med. 7: 290ra92. PMID: 26041709
- β-N-oxalyl-L-α, β- diaminopropionic acid induces HRE expression by inhibiting HIF-prolyl hydroxylase-2 in normoxic conditions. | Eslavath, RK., et al. 2016. Eur J Pharmacol. 791: 405-411. PMID: 27393459
- The nature of early astroglial protection-Fast activation and signaling. | Kardos, J., et al. 2017. Prog Neurobiol. 153: 86-99. PMID: 28342942
- Oxygen, Metabolism, and Regeneration: Lessons from Mice. | Heber-Katz, E. 2017. Trends Mol Med. 23: 1024-1036. PMID: 28988849
- Drug delivery and epimorphic salamander-type mouse regeneration: A full parts and labor plan. | Heber-Katz, E. and Messersmith, P. 2018. Adv Drug Deliv Rev. 129: 254-261. PMID: 29524586
- Proline mediates metabolic communication between retinal pigment epithelial cells and the retina. | Yam, M., et al. 2019. J Biol Chem. 294: 10278-10289. PMID: 31110046
- P4HA1/HIF1α feedback loop drives the glycolytic and malignant phenotypes of pancreatic cancer. | Cao, XP., et al. 2019. Biochem Biophys Res Commun. 516: 606-612. PMID: 31239153
- Upregulating sirtuin 6 ameliorates glycolysis, EMT and distant metastasis of pancreatic adenocarcinoma with krüppel-like factor 10 deficiency. | Tsai, YC., et al. 2021. Exp Mol Med. 53: 1623-1635. PMID: 34702956
- An MMP-degradable and conductive hydrogel to stabilize HIF-1α for recovering cardiac functions. | Wei, X., et al. 2022. Theranostics. 12: 127-142. PMID: 34987638
- The influence of molecular design on structure-property relationships of a supramolecular polymer prodrug. | DeFrates, KG., et al. 2022. Proc Natl Acad Sci U S A. 119: e2208593119. PMID: 36279462
Inhibitor of:
Gα 13, P4HA, and PH-4.Activator of:
HIF-1 alpha, HIF-3α, JMJD7, and Transcription Factor.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
1,4-DPCA, 5 mg | sc-200758 | 5 mg | $68.00 | |||
1,4-DPCA, 25 mg | sc-200758A | 25 mg | $266.00 |