Date published: 2026-5-6

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1,4-Dioxane-d8 (CAS 17647-74-4)

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Alternate Names:
Octadeuterodioxane; p-Dioxane-d8
Application:
1,4-Dioxane-d8 is a useful deuterated dioxane often used as a solvent and stabalizer for 1,1,1-trichloroethane
CAS Number:
17647-74-4
Molecular Weight:
96.15
Molecular Formula:
C4D8O2
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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1,4-Dioxane-d8 is used in chemical research as a stable isotopic labeling compound, particularly in the field of spectroscopy. Its deuterated nature makes it an ideal solvent for nuclear magnetic resonance (NMR) spectroscopy, where it is used to minimize background hydrogen signals, thereby enhancing the clarity and resolution of the spectra of other substances of interest. In addition to its role in NMR, 1,4-Dioxane-d8 is utilized in mass spectrometry studies to help in the accurate determination of molecular weights and structures. Researchers value this compound for its ability to facilitate the identification of complex reaction mechanisms and for tracking the fate of molecules in chemical processes. Furthermore, 1,4-Dioxane-d8 serves as a reference material in quantitative NMR, enabling precise measurements of concentration and purity of samples.


1,4-Dioxane-d8 (CAS 17647-74-4) References

  1. Distribution of 1,4-dioxane in relation to possible sources in the water environment.  |  Abe, A. 1999. Sci Total Environ. 227: 41-7. PMID: 10209880
  2. Ketalization of phosphonium ions by 1,4-dioxane: selective detection of the chemical warfare agent simulant DMMP in mixtures using ion/molecule reactions.  |  Chen, H., et al. 2003. J Am Soc Mass Spectrom. 14: 182-8. PMID: 12648924
  3. The extraction and analysis of 1,4-dioxane from water using solid-phase microextraction coupled with gas chromatography and gas chromatography-mass spectrometry.  |  Shirey, RE. and Linton, CM. 2006. J Chromatogr Sci. 44: 444-50. PMID: 16925942
  4. Determination of 1,4-dioxane in household detergents and cleaners.  |  Tanabe, A. and Kawata, K. 2008. J AOAC Int. 91: 439-44. PMID: 18476359
  5. Biodegradation of 1,4-dioxane and transformation of related cyclic compounds by a newly isolated Mycobacterium sp. PH-06.  |  Kim, YM., et al. 2009. Biodegradation. 20: 511-9. PMID: 19085063
  6. Method development for the analysis of 1,4-dioxane in drinking water using solid-phase extraction and gas chromatography-mass spectrometry.  |  Grimmett, PE. and Munch, JW. 2009. J Chromatogr Sci. 47: 31-9. PMID: 19161654
  7. Peroxone activated persulfate treatment of 1,4-dioxane in the presence of chlorinated solvent co-contaminants.  |  Eberle, D., et al. 2016. Chemosphere. 144: 728-35. PMID: 26408980
  8. Determination of 1,4-Dioxane in the Cape Fear River Watershed by Heated Purge-and-Trap Preconcentration and Gas Chromatography-Mass Spectrometry.  |  Sun, M., et al. 2016. Environ Sci Technol. 50: 2246-54. PMID: 26829406
  9. Neutron Scattering of Residual Hydrogen in 1,4-Dioxane-d8 Liquid: Understanding Measurements with Molecular Dynamics Simulations.  |  de Almeida, VF., et al. 2016. J Phys Chem B. 120: 5455-69. PMID: 27276502
  10. 1,4-Dioxane pollution at contaminated groundwater sites in western Germany and its distribution within a TCE plume.  |  Karges, U., et al. 2018. Sci Total Environ. 619-620: 712-720. PMID: 29166627
  11. Identification of hydroxyl and sulfate free radicals involved in the reaction of 1,4-dioxane with peroxone activated persulfate oxidant.  |  Cashman, MA., et al. 2019. J Hazard Mater. 380: 120875. PMID: 31336268
  12. The determination of 1,4-dioxane in cosmetic products by gas chromatography with tandem mass spectrometry.  |  Zhou, W. 2019. J Chromatogr A. 1607: 460400. PMID: 31405575
  13. Development of a New Polar Organic Chemical Integrative Sampler for 1,4-dioxane Using Silicone Membrane as a Diffusion Barrier.  |  Noro, K., et al. 2023. Environ Toxicol Chem. 42: 296-302. PMID: 36349960

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

1,4-Dioxane-d8, 1 g

sc-255942
1 g
$170.00

1,4-Dioxane-d8, 5 g

sc-255942A
5 g
$580.00