Molecular structure of 1,4-Dimethylendothall, CAS Number: 109282-27-1
1,4-Dimethylendothall (CAS 109282-27-1)
Alternate Names:
1,4-Dimethyl-7-oxabicyclo [2.2.1.]; heptane-2,3-dicarboxylic acid
Application:
1,4-Dimethylendothall is an endothall analog with no PP2A inhibition activity
CAS Number:
109282-27-1
Purity:
≥98%
Molecular Weight:
214.21
Molecular Formula:
C10H14O5
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
QUICK LINKS
Ordering Information
Description
Technical Information
Safety Information
SDS & Certificate of Analysis
1,4-Dimethylendothall is a structural analog of endothall which, unlike endothall, shows no inhibition of PP2A (protein phosphatase 2A) activity. Both molecules are structurally related to cantharidin, a very strong PP2A inhibitor, and 1,4-Dimethylendothall serves as a negative control for endothall and cantharidin in studies probing PP2A activity.
1,4-Dimethylendothall (CAS 109282-27-1) References
- Cantharidin-binding protein: identification as protein phosphatase 2A. | Li, YM. and Casida, JE. 1992. Proc Natl Acad Sci U S A. 89: 11867-70. PMID: 1334551
- Functions of Ceramide Synthase Paralogs YPR114w and YJR116w of Saccharomyces cerevisiae. | Mallela, SK., et al. 2016. PLoS One. 11: e0145831. PMID: 26752183
- Ability of okadaic acid and other protein phosphatase inhibitors to mimic the stimulatory effects of 12-O-tetradecanoylphorbol-13-acetate on hydroperoxide production in mouse epidermis in vivo. | Newell, SW., et al. 1996. Cancer Lett. 98: 241-51. PMID: 8556715
- Protein phosphatase 2A plays a critical role in interleukin-2-induced beta 2-integrin dependent homotypic adhesion in human CD4+ T cell lines. | Brockdorff, J., et al. 1997. Cytokine. 9: 333-9. PMID: 9195132
- Protein phosphatase inhibitors activate defense responses in rice (Oryza sativa) leaves | Randeep Rakwal, Katsuhiko Shii, Ganesh K. Agrawal, Masami Yonekura. 2001. Physiologia Plantarum. 111: 151-157.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
1,4-Dimethylendothall, 10 mg | sc-201327 | 10 mg | $200.00 | |||
1,4-Dimethylendothall, 50 mg | sc-201327A | 50 mg | $400.00 |