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1,4-Dideoxy-1,4-imino-D-arabinitol hydrochloride (CAS 100991-92-2)

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Alternate Names:
(2R,3R,4R)-2-(hydroxymethyl)pyrrolidine-3,4-diol hydrochloride; 2-Hydroxymethyl-3,4-pyrrolidinediol hydrochloride
Application:
1,4-Dideoxy-1,4-imino-D-arabinitol hydrochloride is a glycogen phosphorylase inhibitor
CAS Number:
100991-92-2
Purity:
≥96%
Molecular Weight:
169.61
Molecular Formula:
C5H11NO3•HCl
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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1,4-Dideoxy-1,4-imino-D-arabinitol Hydrochloride is a glycogen phosphorylase inhibitor. It is also an inhibitor of Glucosidase II alpha, PYGB, PYGL and PYGM. 1,4-Dideoxy-1,4-imino-D-arabinitol hydrochloride, a synthetic compound, has found diverse applications in the realms of science and medicine. As a derivative of 1,4-dideoxy-1,4-imino-D-arabinitol, it serves as a building block for the synthesis of numerous compounds, such as nucleoside analogs, polysaccharides, and peptides. Furthermore, its potential has been extensively explored in various in vitro studies. Notably, it has demonstrated promise in elucidating fundamental cellular processes, including cell proliferation, differentiation, and apoptosis. Moreover, researchers have investigated its potential in unraveling the intricate mechanisms of gene expression and signal transduction pathways.


1,4-Dideoxy-1,4-imino-D-arabinitol hydrochloride (CAS 100991-92-2) References

  1. Inhibition of glycogenolysis in primary rat hepatocytes by 1, 4-dideoxy-1,4-imino-D-arabinitol.  |  Andersen, B., et al. 1999. Biochem J. 342 Pt 3: 545-50. PMID: 10477265
  2. Synthesis of naturally occurring iminosugars from D-fructose by the use of a zinc-mediated fragmentation reaction.  |  Lauritsen, A. and Madsen, R. 2006. Org Biomol Chem. 4: 2898-905. PMID: 16855738
  3. Molecular interaction of imino sugars with human alpha-galactosidase: Insight into the mechanism of complex formation and pharmacological chaperone action in Fabry disease.  |  Sugawara, K., et al. 2009. Mol Genet Metab. 96: 233-8. PMID: 19181556
  4. Tissue-type plasminogen activator mediates neuroglial coupling in the central nervous system.  |  An, J., et al. 2014. Neuroscience. 257: 41-8. PMID: 24200922
  5. Glycogen metabolism protects against metabolic insult to preserve carotid body function during glucose deprivation.  |  Holmes, AP., et al. 2014. J Physiol. 592: 4493-506. PMID: 25063821
  6. Single-cell imaging of bioenergetic responses to neuronal excitotoxicity and oxygen and glucose deprivation.  |  Connolly, NM., et al. 2014. J Neurosci. 34: 10192-205. PMID: 25080581
  7. Regulatory volume increase in astrocytes exposed to hypertonic medium requires β1 -adrenergic Na(+) /K(+) -ATPase stimulation and glycogenolysis.  |  Song, D., et al. 2015. J Neurosci Res. 93: 130-9. PMID: 25124094
  8. Astrocytic β2-adrenergic receptors mediate hippocampal long-term memory consolidation.  |  Gao, V., et al. 2016. Proc Natl Acad Sci U S A. 113: 8526-31. PMID: 27402767
  9. Retinal ischemia induces α-SMA-mediated capillary pericyte contraction coincident with perivascular glycogen depletion.  |  Alarcon-Martinez, L., et al. 2019. Acta Neuropathol Commun. 7: 134. PMID: 31429795
  10. Phosphorylase Kinase β Represents a Novel Prognostic Biomarker and Inhibits Malignant Phenotypes of Liver Cancer Cell.  |  Yang, W., et al. 2019. Int J Biol Sci. 15: 2596-2606. PMID: 31754332
  11. Astrocyte L-Lactate Signaling in the ACC Regulates Visceral Pain Aversive Memory in Rats.  |  Iqbal, Z., et al. 2022. Cells. 12: PMID: 36611820
  12. Serotonergic neurons control cortical neuronal intracellular energy dynamics by modulating astrocyte-neuron lactate shuttle.  |  Natsubori, A., et al. 2023. iScience. 26: 105830. PMID: 36713262
  13. Sugars with nitrogen in the ring isolated from the leaves of Morus bombycis.  |  Asano, N., et al. 1994. Carbohydr Res. 253: 235-45. PMID: 8156550

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

1,4-Dideoxy-1,4-imino-D-arabinitol hydrochloride, 10 mg

sc-220553
10 mg
$431.00

1,4-Dideoxy-1,4-imino-D-arabinitol hydrochloride, 25 mg

sc-220553A
25 mg
$1025.00