Date published: 2026-2-10

1-800-457-3801

SCBT Portrait Logo
Seach Input

1,4-Cyclohexadiene (CAS 628-41-1)

0.0(0)
Write a reviewAsk a question

Alternate Names:
1,4-Dihydrobenzene
Application:
1,4-Cyclohexadiene is an effective hydrogen donor
CAS Number:
628-41-1
Molecular Weight:
80.13
Molecular Formula:
C6H8
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

QUICK LINKS

1,4-Cyclohexadiene is useful for the reduction of radical intermediates formed in electron-transfer mediated ring-opening reactions and as an effective hydrogen donor in catalytic hydrogenation reactions. 1,4-Cyclohexadiene forms benzene at elevated temperatures in the presence of a ruthenium(II)-triphenylphosphine catalyst. 1,4-Cyclohexadiene, an organic compound classified within the cycloalkene family of hydrocarbons, presents itself as a colorless liquid with a delightful yet potent aroma. This versatile chemical plays a role in various scientific and industrial endeavors. Serving as a solvent and reagent in organic synthesis, it also acts as a fundamental building block in the creation of diverse organic substances. In scientific applications, 1,4-cyclohexadiene proves invaluable for synthesizing amino acids, peptides, cyclic ethers, alkaloids, and heterocycles. Moreover, its significance extends to pesticide production, where it plays a pivotal role in crafting specialized chemical compounds. One of its outstanding attributes is its electron-rich nature, which empowers it to function as a nucleophile in organic reactions. Through interactions with electrophiles like carbonyl compounds, halides, and aldehydes, it forges new chemical entities. Additionally, it engages with other electron-rich compounds, such as amines and alcohols, facilitating the formation of further compounds. In essence, 1,4-cyclohexadiene stands as an essential component in the realm of organic synthesis, contributing its capabilities to diverse applications and enabling the creation of a vast array of valuable chemical substances.


1,4-Cyclohexadiene (CAS 628-41-1) References

  1. Matrix isolation study of the ozonolysis of 1,3- and 1,4-cyclohexadiene: identification of novel reaction pathways.  |  Pinelo, L., et al. 2013. J Phys Chem A. 117: 4174-82. PMID: 23638640
  2. Dynamic Kerr effect study on six-membered-ring molecular liquids: benzene, 1,3-cyclohexadiene, 1,4-cyclohexadiene, cyclohexene, and cyclohexane.  |  Kakinuma, S. and Shirota, H. 2015. J Phys Chem B. 119: 4713-24. PMID: 25741755
  3. CAP/EA-ADC method for metastable anions: Computational aspects and application to π* resonances of norbornadiene and 1,4-cyclohexadiene.  |  Dempwolff, AL., et al. 2021. J Chem Phys. 155: 054103. PMID: 34364339
  4. Reversible C-C Bond Cleavage of a Cobalt Diketimide into an Elusive Cobalt Aryl Nitrenoid Complex.  |  Baek, Y. and Betley, TA. 2022. Angew Chem Int Ed Engl. 61: e202115437. PMID: 35172039
  5. Planar Chiral Rhodium Complexes of 1,4-Benzoquinones.  |  Ankudinov, NM., et al. 2022. Chemistry. 28: e202200195. PMID: 35176185
  6. Development of an Allenyne-Alkyne [4+2] Cycloaddition and its Application to Total Synthesis of Selaginpulvilin A.  |  Le, A., et al. 2022. Chemistry. 28: e202202015. PMID: 35771213
  7. Unmasking the Iron-Oxo Bond of the [(Ligand)Fe-OIAr]2+/+ Complexes.  |  Tripodi, GL. and Roithová, J. 2022. J Am Soc Mass Spectrom. 33: 1636-1643. PMID: 35920859
  8. Reaction with ROO• and HOO• Radicals of Honokiol-Related Neolignan Antioxidants.  |  Cardullo, N., et al. 2023. Molecules. 28: PMID: 36677790
  9. Theoretical investigation on the elusive structure-activity relationship of bioinspired high-valence nickel-halogen complexes in oxidative fluorination reactions.  |  Zhou, A., et al. 2023. Dalton Trans. 52: 1977-1988. PMID: 36691931
  10. Light-Assisted Synthesis of Silver and Gold Nanoparticles by New Benzophenone Derivatives.  |  Alnafisah, AS., et al. 2023. ACS Omega. 8: 3207-3220. PMID: 36713746
  11. A Neutral Borylene and its Conversion to a Radical by Selective Hydrogen Transfer.  |  Nazish, M., et al. 2023. Inorg Chem. 62: 9343-9349. PMID: 37294916
  12. Pd-Catalyzed 1,3-Alkenylarylation of Skipped Diene via Metal Migration.  |  Chesley, LJ., et al. 2023. ACS Omega. 8: 19912-19916. PMID: 37305246
  13. Three oxidative addition routes of alkali metal aluminyls to dihydroaluminates and reactivity with CO2.  |  Banerjee, S., et al. 2023. Chemistry. e202301849. PMID: 37429823

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

1,4-Cyclohexadiene, 5 ml

sc-255936
5 ml
$55.00

1,4-Cyclohexadiene, 25 ml

sc-255936A
25 ml
$195.00