Date published: 2025-12-15

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1,4-Bis(acryloyl)piperazine (CAS 6342-17-2)

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Alternate Names:
1,4-Diacryloylpiperazine
Application:
1,4-Bis(acryloyl)piperazine is a polyacrylamide gel cross-linker used to reduces silver-staining background
CAS Number:
6342-17-2
Purity:
97%
Molecular Weight:
194.23
Molecular Formula:
C10H14N2O2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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1,4-Bis(acryloyl)piperazine is a cross-linker on polyacrylamide gels which reduces background staining on silver-stained gels. In addition, studies suggest that 1,4-Bis(acryloyl)piperazine has been shown to improve electrophoretic separation of proteins and nuclei acids compared to other cross-linkers.


1,4-Bis(acryloyl)piperazine (CAS 6342-17-2) References

  1. Novel therapeutic agents for bone resorption. Part 1. Synthesis and protonation thermodynamics of poly(amido-amine)s containing bis-phosphonate residues.  |  Casolaro, M., et al. 2006. Biomacromolecules. 7: 3417-27. PMID: 17154470
  2. Poly(amidoamine) conjugates with disulfide-linked cholesterol pendants self-assembling into redox-sensitive nanoparticles.  |  Ranucci, E., et al. 2008. Biomacromolecules. 9: 2693-704. PMID: 18781798
  3. Degradable poly(amidoamine) hydrogels as scaffolds for in vitro culturing of peripheral nervous system cells.  |  Mauro, N., et al. 2013. Macromol Biosci. 13: 332-47. PMID: 23239646
  4. Influence of the crosslinker type on the chromatographic properties of hydrophilic sulfoalkylbetaine-type monolithic columns.  |  Liu, C., et al. 2014. J Chromatogr A. 1373: 73-80. PMID: 25464999
  5. Effect of the crosslinker type on the enantioseparation performance of β-cyclodextrin functionalized monoliths prepared by the one-pot approach.  |  Guo, J., et al. 2016. J Chromatogr A. 1467: 288-296. PMID: 27268520
  6. Enzyme-Initiated Free-Radical Polymerization of Molecularly Imprinted Polymer Nanogels on a Solid Phase with an Immobilized Radical Source.  |  Daoud Attieh, M., et al. 2017. Angew Chem Int Ed Engl. 56: 3339-3343. PMID: 28194847
  7. Development of polyacrylamide gels that improve the separation of proteins and their detection by silver staining.  |  Hochstrasser, DF., et al. 1988. Anal Biochem. 173: 412-23. PMID: 3189819
  8. Methods for increasing the resolution of two-dimensional protein electrophoresis.  |  Hochstrasser, DF., et al. 1988. Anal Biochem. 173: 424-35. PMID: 3189820
  9. Fabrication and application of zwitterionic phosphorylcholine functionalized monoliths with different hydrophilic crosslinkers in hydrophilic interaction chromatography.  |  Wang, Q., et al. 2020. Anal Chim Acta. 1101: 222-229. PMID: 32029114
  10. Fractionation techniques in a hydro-organic environment. II. Acryloyl-morpholine polymers as a matrix for electrophoresis in hydro-organic solvents.  |  Artoni, G., et al. 1984. Anal Biochem. 137: 420-8. PMID: 6731826

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

1,4-Bis(acryloyl)piperazine, 5 g

sc-203424
5 g
$150.00

1,4-Bis(acryloyl)piperazine, 10 g

sc-203424A
10 g
$260.00