Date published: 2025-12-18

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1,4-Anhydro-D-sorbitol (CAS 27299-12-3)

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Alternate Names:
1,4-Anhydro-D-glucitol; 1,4-Anhydroglucitol; 1,4-Sorbitan
Application:
1,4-Anhydro-D-sorbitol is a useful intermediate in Prostaglandin synthesis
CAS Number:
27299-12-3
Purity:
≥97%
Molecular Weight:
164.16
Molecular Formula:
C6H12O5
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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1,4-anhydro-D-sorbitol, also known as Sorbitan, is a sugar alcohol derivative of sorbitol. It is a natural sugar alcohol that is derived from glucose. It is utilized in the production of polymers, such as polyesters and polycarbonates, as well as in the formulation of pharmaceutical drugs. 1,4-anhydro-D-sorbitol is utilized in pharmaceutical formulations as a solubilizing agent.


1,4-Anhydro-D-sorbitol (CAS 27299-12-3) References

  1. Intercalation-controlled cyclodehydration of sorbitol in water over layered-niobium-molybdate solid acid.  |  Morita, Y., et al. 2014. ChemSusChem. 7: 748-52. PMID: 24478140
  2. Intramolecular dehydration of biomass-derived sugar alcohols in high-temperature water.  |  Yamaguchi, A., et al. 2017. Phys Chem Chem Phys. 19: 2714-2722. PMID: 27896339
  3. Kinetic analyses of intramolecular dehydration of hexitols in high-temperature water.  |  Yamaguchi, A., et al. 2020. Carbohydr Res. 487: 107880. PMID: 31785566
  4. Aqueous Room Temperature Mono-Dehydration of Sugar Alcohols Using Functionalized Yttrium Oxide Nanocatalysts.  |  Yang, J., et al. 2020. Front Chem. 8: 532. PMID: 32793546
  5. High-temperature solvent-free synthesis of low-molecular-weight organogelators consisting of starch-derived 1,5-anhydro-d-glucitol coupled with fatty acids.  |  Komba, S. and Iwaura, R. 2023. RSC Adv. 13: 9316-9321. PMID: 36959883
  6. Esterification of sorbitol and lauric acid with catalystp-TSA  |  Giacometti, J., Wolf, N., Gomzi, Z., & Milin, C. 1996. Reaction Kinetics and Catalysis Letters. 59: 235-240.
  7. Sorbitol dehydration in high temperature liquid water  |  Yamaguchi, A., Hiyoshi, N., Sato, O., & Shirai, M. 2011. Green Chemistry. 873-881.
  8. Selective dehydration of sorbitol to 1,4-anhydro-d-sorbitol catalyzed by a polymer-supported acid catalyst  |  Xiu, Y., Chen, A., Liu, X., Chen, C., Chen, J., Guo, L.,.. & Hou, Z. 2015. RSC Advances. 5(36): 28233-28241.
  9. Hydrophilic sulfonic acid-functionalized micro-bead silica for dehydration of sorbitol to isosorbide  |  Shi, J., Shan, Y., Tian, Y., Wan, Y., Zheng, Y., & Feng, Y. 2016. RSC advances. 6(16): 13514-13521.
  10. Dehydration of sorbitol to isosorbide over sulfonic acid resins under solvent-free conditions  |  Ginés-Molina, M. J., Moreno-Tost, R., Santamaría-González, J., & Maireles-Torres, P. 2017. Applied Catalysis A: General. 537: 66-73.
  11. Catalytic dehydration of sorbitol and fructose by acid-modified zirconium phosphate  |  Ni, W., Li, D., Zhao, X., Ma, W., Kong, K., Gu, Q.,.. & Hou, Z. 2019. Catalysis Today. 319: 66-75.
  12. Efficient and selective aqueous photocatalytic mono-dehydration of sugar alcohols using functionalized yttrium oxide nanocatalysts  |  Yang, J., Li, X., Cheng, Y., Fan, C., Pan, C., Huang, B.,.. & Sun, Y. 2020. Green Chemistry. 22(16): 5333-5344.
  13. Photoactive CeO2/SBA-15 functionalized materials as efficient systems for mono-dehydration of sugar alcohols  |  Yang, J., Jia, Y., Huang, B., Li, X., Guo, L., Zheng, A.,.. & Sun, Y. 2020. Molecular Catalysis. 487: 110844.

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

1,4-Anhydro-D-sorbitol, 1 g

sc-220552
1 g
$377.00