1,4,8,11-Tetraazacyclotetradecane-1,4,8,11-tetraacetic acid tetrahydrochloride tetrahydrate (CAS 78668-42-5)

1,4,8,11-Tetraazacyclotetradecane-1,4,8,11-tetraacetic acid tetrahydrochloride tetrahydrate, known by the acronym TETA, is a chelating agent that has found extensive use in coordination chemistry and radiopharmaceutical research. As a tetraazamacrocycle with four acetate groups, 1,4,8,11-Tetraazacyclotetradecane-1,4,8,11-tetraacetic acid tetrahydrochloride tetrahydrate is able to form stable complexes with various metal ions, a property that is particularly valuable when studying transition metal chemistry. In the field of diagnostic imaging, 1,4,8,11-Tetraazacyclotetradecane-1,4,8,11-tetraacetic acid tetrahydrochloride tetrahydrate and its derivatives are investigated for their potential to act as stable chelators for radioactive isotopes in the development of radiotracers for positron emission tomography (PET) and single-photon emission computed tomography (SPECT) imaging. Furthermore, studies involving 1,4,8,11-Tetraazacyclotetradecane-1,4,8,11-tetraacetic acid tetrahydrochloride tetrahydrate contribute to the understanding of metal ion transport and storage within biological systems. Its role in the synthesis of contrast agents for magnetic resonance imaging (MRI) is another area of application, where its chelating properties are used to enhance the contrast of images.